All Phenotypes Gpx4<tm2Marc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gpx4^tm2Marc
targeted mutation 2, Marcus Conrad
MGI:3810783

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gpx4^tm2Marc/Gpx4^tm2Marc Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/0	involves: 129P2/OlaHsd	MGI:8350573
cn2	Gpx4^em1Marc/Gpx4^tm2Marc Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/0	involves: 129P2/OlaHsd * C57BL/6J	MGI:8350568
cn3	Gpx4^em1Marc/Gpx4^tm2Marc Tg(Camk2a-cre/ERT2)2Gsc/0	involves: 129P2/OlaHsd * C57BL/6J * FVB/N	MGI:8350560
cn4	Gpx4^tm2Marc/Gpx4^tm2Marc Tg(Camk2a-cre)2Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:7528942
cn5	Gpx4^tm2Marc/Gpx4^tm2Marc Tg(Camk2a-cre/ERT2)2Gsc/0	involves: 129P2/OlaHsd * FVB/N	MGI:8350567
cn6	Gpx4^tm2Marc/Gpx4^tm2Marc Tg(Pcp2-cre)2Mpin/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:8350576

Allelic Composition	Gpx4^tm2Marc/Gpx4^tm2Marc Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (1211 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased ferroptosis ( J:385850 )

• renal proximal tubule epithelia cell death by ferroptosis after tamoxifen administration

growth/size/body

weight loss ( J:385850 )

• owing to acute kidney failure after tamoxifen administration

homeostasis/metabolism

increased circulating creatinine level ( J:385850 )

• after tamoxifen administration

increased circulating bilirubin level ( J:385850 )

• after tamoxifen administration

increased circulating alanine transaminase level ( J:385850 )

• after tamoxifen administration

increased circulating aspartate transaminase level ( J:385850 )

• after tamoxifen administration

increased circulating lactate dehydrogenase level ( J:385850 )

• after tamoxifen administration

decreased circulating serum albumin level ( J:385850 )

• after tamoxifen administration

increased blood urea nitrogen level ( J:385850 )

• after tamoxifen administration

mortality/aging

premature death ( J:385850 )

• acute kidney failure leads to death 10-12 after tamoxifen administration

renal/urinary system

renal necrosis ( J:385850 )

• renal proximal tubule epithelia cell death by ferroptosis after tamoxifen administration

Allelic Composition	Gpx4^em1Marc/Gpx4^tm2Marc Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn}/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^em1Marc mutation (0 available); any Gpx4 mutation (80 available)
Gpx4^tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Gt(ROSA)26Sor^{tm2(cre/ERT2)Brn} mutation (1 available); any Gt(ROSA)26Sor mutation (1211 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased ferroptosis ( J:385850 )

• renal proximal tubule epithelia cell death by ferroptosis after tamoxifen administration

growth/size/body

weight loss ( J:385850 )

• owing to acute kidney failure after tamoxifen administration

homeostasis/metabolism

increased circulating creatinine level ( J:385850 )

• after tamoxifen administration

increased circulating bilirubin level ( J:385850 )

• after tamoxifen administration

increased circulating alanine transaminase level ( J:385850 )

• after tamoxifen administration

increased circulating aspartate transaminase level ( J:385850 )

• after tamoxifen administration

increased circulating lactate dehydrogenase level ( J:385850 )

• after tamoxifen administration

decreased circulating serum albumin level ( J:385850 )

• after tamoxifen administration

increased blood urea nitrogen level ( J:385850 )

• after tamoxifen administration

mortality/aging

premature death ( J:385850 )

• acute kidney failure leads to death 10-12 after tamoxifen administration

renal/urinary system

renal necrosis ( J:385850 )

• renal proximal tubule epithelia cell death by ferroptosis after tamoxifen administration

Allelic Composition	Gpx4^em1Marc/Gpx4^tm2Marc Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased vertical activity ( J:385850 )

• after tamoxifen administration

decreased locomotor activity ( J:385850 )

• after tamoxifen administration

cellular

increased ferroptosis ( J:385850 )

• cerebral cortex degeneration caused by ferroptosis of neurons

nervous system

decreased cerebral cortex cell number ( J:385850 )

• atrophy after tamoxifen administration

disorganized cerebral cortex lamination ( J:385850 )

• disorganized after tamoxifen administration

thin cerebral cortex ( J:385850 )

• atrophy after tamoxifen administration

Allelic Composition	Gpx4^tm2Marc/Gpx4^tm2Marc Tg(Camk2a-cre)2Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Tg(Camk2a-cre)2Gsc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:139668 )

• mice were euthanized at 13 days of age due to no weight gain and seizures

nervous system

convulsive seizures ( J:139668 )

• 12 day old pups suffer seizures when touched by littermates

astrocytosis ( J:139668 )

• astrogliosis occurs in the somatosensory cortex and the CA3 region of the hippocampus of 13-day old mice

increased neuron apoptosis ( J:139668 )

• E15.5 cortical neurons cultured in vitro die within 7 days of withdrawal of the anti-oxidant alpha-tocopherol

• this cell death occurs by a poorly defined death pathway involving the protein Aifm1

abnormal hippocampus CA3 region morphology ( J:139668 )

• damaged and pyknotic cells in the pyramidal layer of the CA3 region are found in mice 13 days of age

• parvalbumin-positive cells were largely lost from CA3 region due to apoptosis

abnormal somatosensory cortex morphology ( J:139668 )

• astrogliosis, apoptosis, and loss of parvalbumin-expressing cells occur in the somatosensory cortex of 13 day old mice

growth/size/body

weight loss ( J:139668 )

• mice cease weight gain starting at 8 days of age until being euthanized at 13 days of age

behavior/neurological

ataxia ( J:139668 )

• is apparent at 10 days of age

abnormal social/conspecific interaction behavior ( J:139668 )

• mice consistently bury themselves vertically in cage bedding

convulsive seizures ( J:139668 )

• 12 day old pups suffer seizures when touched by littermates

cellular

astrocytosis ( J:139668 )

• astrogliosis occurs in the somatosensory cortex and the CA3 region of the hippocampus of 13-day old mice

increased neuron apoptosis ( J:139668 )

• E15.5 cortical neurons cultured in vitro die within 7 days of withdrawal of the anti-oxidant alpha-tocopherol

• this cell death occurs by a poorly defined death pathway involving the protein Aifm1

Allelic Composition	Gpx4^tm2Marc/Gpx4^tm2Marc Tg(Camk2a-cre/ERT2)2Gsc/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased vertical activity ( J:385850 )

• after tamoxifen administration

decreased locomotor activity ( J:385850 )

• after tamoxifen administration

cellular

astrocytosis ( J:385850 )

• in cerebral cortex from 1 week after tamoxifen administration

microgliosis ( J:385850 )

• in cerebral cortex from 2 weeks after tamoxifen administration

increased ferroptosis ( J:385850 )

• cerebral cortex degeneration caused by ferroptosis of neurons

hematopoietic system

microgliosis ( J:385850 )

• in cerebral cortex from 2 weeks after tamoxifen administration

immune system

microgliosis ( J:385850 )

• in cerebral cortex from 2 weeks after tamoxifen administration

nervous system

astrocytosis ( J:385850 )

• in cerebral cortex from 1 week after tamoxifen administration

microgliosis ( J:385850 )

• in cerebral cortex from 2 weeks after tamoxifen administration

decreased cerebral cortex cell number ( J:385850 )

• atrophy after tamoxifen administration

disorganized cerebral cortex lamination ( J:385850 )

• disorganized after tamoxifen administration

thin cerebral cortex ( J:385850 )

• atrophy after tamoxifen administration

Allelic Composition	Gpx4^tm2Marc/Gpx4^tm2Marc Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpx4^tm2Marc mutation (0 available); any Gpx4 mutation (80 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:385850 )

• from age 6 weeks

cellular

astrocytosis ( J:385850 )

• from age 6 weeks

microgliosis ( J:385850 )

• from age 6 weeks

embryo

embryo phenotype ( J:385850 )

N	• mice born at expected Mendelian ratios

hematopoietic system

microgliosis ( J:385850 )

• from age 6 weeks

immune system

microgliosis ( J:385850 )

• from age 6 weeks

nervous system

astrocytosis ( J:385850 )

• from age 6 weeks

microgliosis ( J:385850 )

• from age 6 weeks

Purkinje cell degeneration ( J:385850 )

• near absence of calbindin+ Purkinje neurons from age 6 weeks

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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