Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(CAG-EGFP/CETN2)3-4Jgg transgene insertion 3-4, Joseph G Gleeson MGI:3793421 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit normal body weights and do not develop hydrocephalus, unlike males carrying the Cetn2tm1.1Wbae allele
• mice are rescued from the OSN ciliary trafficking defect, as shown by normal ciliary localizations of two major transmembrane signaling proteins (ACIII and CNGA2), and a peripheral membrane-associated protein
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very few cells from E9.0 embryos show centrioles (2% compared to 98% in wild-type embryos)
• in cultured ES cells almost half of all centrioles are abnormal, about one third have normal-like centrioles, and the rest have thread-like structures
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• very few cells from E9.0 embryos show centrioles (6% compared to 98% in wild-type embryos)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• regions of cerebellum and ventricular zone show no increased levels of apoptosis or pyknotic nuclei compared to wild-type embryos
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• intracellular GFP-expressing aggregates are observed exclusively in the adult brain in specific regions (T.G.G. personal comm.)
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/29/2025 MGI 6.24 |
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