Cetn2^tm1.1Wbae
Targeted Allele Detail

Summary

• Symbol: Cetn2^tm1.1Wbae
• Name: centrin 2; targeted mutation 1.1, Wolfgang Baehr
• MGI ID: MGI:5634782
• Synonyms: Cetn2^deltaEx2,3
• Gene: Cetn2 Location: ChrX:71957137-71961967 bp, - strand Genetic Position: ChrX, 37.29 cM, cytoband B
• Alliance: Cetn2^tm1.1Wbae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211061
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Mice carrying the Cetn2^tm1Wbae allele were crossed with an EIIa-Cre driver to eliminate the neo cassette and delete exons 2 and 3. Truncated mRNA (encompassing exons 1, 4, and 5) was detectable by RT/PCR but at very low levels (5-10% of wild-type). The truncated protein was undetectable in mutant olfactory epithelia by immunostaining, indicating that this is a null allele. (J:211061)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cetn2 Mutation: 4 strains or lines available

References

• Original: J:211061 Ying G, et al., Centrin 2 is required for mouse olfactory ciliary trafficking and development of ependymal cilia planar polarity. J Neurosci. 2014 Apr 30;34(18):6377-88
• All: 2 reference(s)