Sass6^em1Baz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sass6^em1Baz
• Name: SAS-6 centriolar assembly protein; endonuclease-mediated mutation 1, Hisham Bazzi
• MGI ID: MGI:8242359
• Synonyms: Sass6^em4, Sass6^em4/Baz
• Gene: Sass6 Location: Chr3:116388631-116424653 bp, + strand Genetic Position: Chr3, 50.4 cM, cytoband G2
• Alliance: Sass6^em1Baz page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs targeting exon 4 created a 3 bp deletion and 1 bp insertion (NC_000069.7(Chr3)*:g.116399341_116399343delinsC). Western blot analysis indicated that protein levels are drastically reduced. (J:347621)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sass6 Mutation: 33 strains or lines available

References

• Original: J:347621 Grzonka M, et al., Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells. Elife. 2024 Feb 26;13
• All: 1 reference(s)