All Phenotypes Sh2d1a<tm2Vei> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sh2d1a^tm2Vei/Sh2d1a^tm2Vei Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3775442
cn2	Sh2d1a^tm2Vei/Sh2d1a^tm2Vei Tg(Lck-cre)1Cwi/0	involves: C57BL/6	MGI:3775441
cn3	Sh2d1a^tm2Vei/Sh2d1a^tm2Vei Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:3775439

Allelic Composition	Sh2d1a^tm2Vei/Sh2d1a^tm2Vei Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Sh2d1a^tm2Vei mutation (0 available); any Sh2d1a mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:131618 )

N	• unlike other conditional knockouts of Apcs, mice exhibit normal numbers of NK T cells, normal antibody response and normal germinal center B cell numbers

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased germinal center B cell number ( J:131618 )

decreased NK T cell number ( J:131618 )

• the number of NK T cells is decreased 90% compared to in wild-type mice

decreased IgE level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG1 level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG2a level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG2b level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG3 level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgM level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

hematopoietic system

decreased germinal center B cell number ( J:131618 )

decreased NK T cell number ( J:131618 )

• the number of NK T cells is decreased 90% compared to in wild-type mice

decreased IgE level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG1 level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG2a level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG2b level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgG3 level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

decreased IgM level ( J:131618 )

• in most mice following immunization with TNP-CGG

• however, some mice could mount a partial antibody response

Allelic Composition	Sh2d1a^tm2Vei/Sh2d1a^tm2Vei Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh2d1a^tm2Vei mutation (0 available); any Sh2d1a mutation (10 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased germinal center B cell number ( J:131618 )

decreased NK T cell number ( J:131618 )

• the number of NK T cells is decreased 30% to 50% compared to in wild-type mice

decreased IgE level ( J:131618 )