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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tet2+
wild type
MGI:3774165
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tet2Gt(AN0709)Wtsi/Tet2+ B6.129P2-Tet2Gt(AN0709)Wtsi MGI:5141272
ht2
 		Tet2tm1.1Mjxu/Tet2+ involves: 129 * C57BL/6 MGI:5301346
cn3
 		Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2+
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0 		involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB MGI:7439999
cn4
 		Tet2tm1.1Iaai/Tet2+
Tg(VAV1-cre)1Graf/0 		involves: 129S/SvEv * C57BL/6 MGI:5141145


Genotype
MGI:5141272
ht1
Allelic
Composition		 Tet2Gt(AN0709)Wtsi/Tet2+
Genetic
Background		 B6.129P2-Tet2Gt(AN0709)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet2Gt(AN0709)Wtsi mutation (0 available); any Tet2 mutation (783 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:174052 )
• some aged mice develop a lethal phenotype

hematopoietic system
abnormal monocyte differentiation ( J:174052 )
• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice
anemia ( J:174052 )
• in some aged mice
increased erythroid progenitor cell number ( J:174052 )
• some aged mice exhibit erythroid lineage hyperplasia with abnormal myelononocytic differentiation compared with wild-type mice
decreased erythrocyte cell number ( J:174052 )
• in some aged mice
thrombocytopenia ( J:174052 )
• in some aged mice
increased leukocyte cell number ( J:174052 )
• in some aged mice
increased monocyte cell number ( J:174052 )
• mice exhibit increased myelomonocytic cells compared with control mice
abnormal spleen morphology ( J:174052 )
• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice
enlarged spleen ( J:174052 )
• massive in some aged mice

liver/biliary system
enlarged liver ( J:174052 )
• massive in some aged mice
liver inflammation ( J:174052 )
• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice
liver fibrosis ( J:174052 )
• moderate in some aged mice

growth/size/body
weight loss ( J:174052 )
• in some aged mice
enlarged liver ( J:174052 )
• massive in some aged mice
enlarged spleen ( J:174052 )
• massive in some aged mice

immune system
abnormal monocyte differentiation ( J:174052 )
• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice
increased leukocyte cell number ( J:174052 )
• in some aged mice
increased monocyte cell number ( J:174052 )
• mice exhibit increased myelomonocytic cells compared with control mice
abnormal spleen morphology ( J:174052 )
• some aged mice exhibit complete spleen effacement and fibrosis unlike wild-type mice
enlarged spleen ( J:174052 )
• massive in some aged mice
liver inflammation ( J:174052 )
• some aged mice exhibit massive perivascular and interstitial infiltration of the liver with myeloid elements unlike wild-type mice

cellular
abnormal monocyte differentiation ( J:174052 )
• some aged mice exhibit abnormal myelononocytic differentiation compared with wild-type mice




Genotype
MGI:5301346
ht2
Allelic
Composition		 Tet2tm1.1Mjxu/Tet2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet2tm1.1Mjxu mutation (0 available); any Tet2 mutation (783 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:178415 )
• by 1 year of age, 5 of 66 mice are moribund compared with no wild-type mice

hematopoietic system
enlarged spleen ( J:178415 )
• in moribund mice at 1 year of age
myeloid hyperplasia ( J:178415 )
• 2 of 5 mice develop myeloproliferative-like myeloid leukemia
• 3 of 5 mice develop chronic myelomonocytic leukemia
increased monocyte cell number ( J:178415 )
• in 2 of 24 mice

neoplasm
increased leukemia incidence ( J:178415 )
• 2 of 5 mice develop myeloproliferative-like myeloid leukemia
• 3 of 5 mice develop chronic myelomonocytic leukemia
increased chronic myelocytic leukemia incidence ( J:178415 )
• 3 of 5 mice develop chronic myelomonocytic leukemia

immune system
enlarged spleen ( J:178415 )
• in moribund mice at 1 year of age
myeloid hyperplasia ( J:178415 )
• 2 of 5 mice develop myeloproliferative-like myeloid leukemia
• 3 of 5 mice develop chronic myelomonocytic leukemia
increased monocyte cell number ( J:178415 )
• in 2 of 24 mice

growth/size/body
enlarged spleen ( J:178415 )
• in moribund mice at 1 year of age




Genotype
MGI:7439999
cn3
Allelic
Composition		 Tet1tm1.2Jae/Tet1tm1.2Jae
Tet2tm1.1Iaai/Tet2+
Tet3tm1.1Yzhg/Tet3tm1.1Yzhg
Tg(Rorc-cre)1Litt/0
Genetic
Background		 involves: 129 * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet1tm1.2Jae mutation (0 available); any Tet1 mutation (147 available)
Tet2tm1.1Iaai mutation (3 available); any Tet2 mutation (783 available)
Tet3tm1.1Yzhg mutation (0 available); any Tet3 mutation (60 available)
Tg(Rorc-cre)1Litt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased effector memory T-helper cell number ( J:333574 )
• greatly reduced CD4 expression upon T cell proliferation

immune system
immune system phenotype ( J:333574 )
N
• no autoimmune phenotypes
• normal spleen and lymph node size
• normal proportions of naive CD44- CD62L+ T lymphocyte compartments
decreased effector memory T-helper cell number ( J:333574 )
• greatly reduced CD4 expression upon T cell proliferation




Genotype
MGI:5141145
cn4
Allelic
Composition		 Tet2tm1.1Iaai/Tet2+
Tg(VAV1-cre)1Graf/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tet2tm1.1Iaai mutation (3 available); any Tet2 mutation (783 available)
Tg(VAV1-cre)1Graf mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased leukocyte cell number ( J:174053 )
• progressive in the peripheral blood
increased monocyte cell number ( J:174053 )
• in the peripheral blood
abnormal hematopoietic stem cell physiology ( J:174053 )
• hematopoietic progenitors exhibit increased serial replating capacity compared with control cells

immune system
increased leukocyte cell number ( J:174053 )
• progressive in the peripheral blood
increased monocyte cell number ( J:174053 )
• in the peripheral blood




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory