Tet1^tm1.2Jae
Targeted Allele Detail

Summary

• Symbol: Tet1^tm1.2Jae
• Name: tet methylcytosine dioxygenase 1; targeted mutation 1.2, Rudolf Jaenisch
• MGI ID: MGI:5911447
• Synonyms: Tet1:flox
• Gene: Tet1 Location: Chr10:62640349-62723242 bp, - strand Genetic Position: Chr10, 32.48 cM
• Alliance: Tet1^tm1.2Jae page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228945
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT site flanked neo cassette with a downstream loxP site was inserted upstream of exon 5. A second loxP site was inserted upstream of exon 4. Flp-mediated recombination removed the neo cassette leaving exon 4 floxed. (J:175858, J:228945)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tet1 Mutation: 142 strains or lines available

References

• Original: J:228945 Zhao Z, et al., Combined Loss of Tet1 and Tet2 Promotes B Cell, but Not Myeloid Malignancies, in Mice. Cell Rep. 2015 Nov 24;13(8):1692-704
• All: 8 reference(s)