All Phenotypes Tg(Tyr-NRAS*Q61K)1Bee MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Tyr-NRAS*Q61K)1Bee
transgene insertion 1, Friedrich Beemann
MGI:3768645

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Trp53^tm1Brn/Trp53^tm1Brn Tg(Tyr-cre/ERT2)13Bos/0 Tg(Tyr-NRAS*Q61K)1Bee/0	FVB.Cg-Tg(Tyr-cre/ERT2)13Bos Trp53^tm1Brn Tg(Tyr-NRAS*Q61K)1Bee	MGI:5645995
cn2	Sox10^{tm7.1(Sox10)Weg}/Sox10⁺ Tg(Tyr-cre/ERT2)13Bos/0 Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2 * FVB/N	MGI:5515811
cx3	Cdk4^tm1.1Bbd/Cdk4^tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee/0	FVB.Cg-Cdk4^tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee	MGI:5645990
cx4	Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2	MGI:5515810
cx5	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL	MGI:5515809
cx6	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(Tyr-NRAS*Q61K)1Bee/?	involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:3768653
cx7	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/?	involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:3768649
cx8	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0	involves: 129/Sv * C57BL/6J * DBA/2 * SJL	MGI:5515807
cx9	Tg(Tyr-DT)3Bee/? Tg(Tyr-NRAS*Q61K)1Bee/?	involves: C57BL/6 * DBA/2	MGI:3768650
tg10	Tg(Tyr-NRAS*Q61K)1Bee/0	involves: C57BL/6J * DBA/2	MGI:5515808
tg11	Tg(Tyr-NRAS*Q61K)1Bee/?	involves: BALB/c * C57BL/6J * DBA/2	MGI:3768651
tg12	Tg(Tyr-NRAS*Q61K)1Bee/?	involves: C57BL/6J * DBA/2	MGI:3768652

Allelic Composition	Trp53^tm1Brn/Trp53^tm1Brn Tg(Tyr-cre/ERT2)13Bos/0 Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	FVB.Cg-Tg(Tyr-cre/ERT2)13Bos Trp53^tm1Brn Tg(Tyr-NRAS*Q61K)1Bee

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:222847 )

• spontaneous development of malignant melanoma by 200 days of age in all mice treated with tamoxifen

• tumors of tamoxifen-treated mice are relatively small, with regular ovoid shape and high levels of Ki-67 staining

• naevi are not seen above dermal malignant melanomas in tamoxifen treated mice, although small nests of melanocytes in a subepidermal location are occasionally seen

• early lesions of tamoxifen treated mice do not show evidence of tumor derivation from the upper dermis and appear to be derived from follicular or other deep dermal precursors

• majority of tumors of tamoxifen treated mice are located on the back

increased incidence of tumors by UV-induction ( J:222847 )

• all mice treated with tamoxifen develop malignant melanoma before 150 days of age after a single neonatal UVB dose

• tamoxifen-treated mice show a diminished response of melanocyte emigration from the upper regions of hair follicles to the epidermal basal layer 3-5 days after neonatal UV radiation compared to controls

integument

increased cutaneous melanoma incidence ( J:222847 )

• spontaneous development of malignant melanoma by 200 days of age in all mice treated with tamoxifen

• tumors of tamoxifen-treated mice are relatively small, with regular ovoid shape and high levels of Ki-67 staining

• naevi are not seen above dermal malignant melanomas in tamoxifen treated mice, although small nests of melanocytes in a subepidermal location are occasionally seen

• early lesions of tamoxifen treated mice do not show evidence of tumor derivation from the upper dermis and appear to be derived from follicular or other deep dermal precursors

• majority of tumors of tamoxifen treated mice are located on the back

Allelic Composition	Sox10^{tm7.1(Sox10)Weg}/Sox10⁺ Tg(Tyr-cre/ERT2)13Bos/0 Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^{tm7.1(Sox10)Weg} mutation (0 available); any Sox10 mutation (33 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:193443 )

N	• mice injected with tamoxifen at 2 months of age do not exhibit hyperpigmentation in the back skin, snout and paws at 12 months of age, indicating reversion of lesions that are seen in single Tg(Tyr-NRAS*Q61K)1Bee mutants

Allelic Composition	Cdk4^tm1.1Bbd/Cdk4^tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	FVB.Cg-Cdk4^tm1.1Bbd Tg(Tyr-NRAS*Q61K)1Bee

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4^tm1.1Bbd mutation (0 available); any Cdk4 mutation (57 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:222847 )

• spontaneous development of malignant melanoma by 300 days of age in all mice

• malignant melanomas have the appearance of nodular lesions and tumors show larger and more pleomorphic nuclei, abundant cytoplasm and numerous multinucleated giant cells and low levels of Ki-67 staining

• two distinct malignant melanoma subtypes are seen: 55% of melanomas are in the deep dermis, separated from the naevus cells above by layers of collagen, while 42% of lesions encompass the subepidermal location of the naevi and appear to be expanded naevi, although cells have morphological features of malignancy

• majority of tumors are located on the back

increased incidence of tumors by UV-induction ( J:222847 )

• mice develop malignant melanoma by 200 days of age after a single neonatal UVB dose

• melanocyte migration from the follicular outer root sheath into the epidermis after neonatal UV radiation is normal

pigmentation

abnormal melanocyte proliferation ( J:222847 )

• mice develop dermal melanocyte proliferations that are similar to superficial cogenital naevi

increased melanocyte number ( J:222847 )

• neonates exhibit a higher number of dermal melanocytes

integument

skin lesions ( J:222847 )

• naevi are nearly always observed immediately beneath the epidermis in a band-like distribution, reminiscent of naevus cells, above lesions

increased cutaneous melanoma incidence ( J:222847 )

• spontaneous development of malignant melanoma by 300 days of age in all mice

• majority of tumors are located on the back

cellular

abnormal melanocyte proliferation ( J:222847 )

• mice develop dermal melanocyte proliferations that are similar to superficial cogenital naevi

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:222847

Allelic Composition	Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:193443 )

N	• hyperproliferation is not observed in the melanocytic cells localized to hair follicles as is seen in single Tg(Tyr-NRAS*Q61K)1Bee mutants

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Sox10^tm1Weg/Sox10⁺ Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Sox10^tm1Weg mutation (1 available); any Sox10 mutation (33 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

pigmentation phenotype ( J:193443 )

N	• loss of the hyperpigmentation that is seen in Cdkn2a^tm1Rdp/ Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0 mice resulting in an almost normal pigmentation pattern

neoplasm

neoplasm ( J:193443 )

N	• no signs of primary melanoma formation are seen at 6 months of age

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a⁺ Tg(Tyr-NRAS*Q61K)1Bee/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:98545 )

• 15 of 18 mice develop cutaneous melanomas within 12 months of birth

integument

increased cutaneous melanoma incidence ( J:98545 )

• 15 of 18 mice develop cutaneous melanomas within 12 months of birth

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:98545

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/?
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased cutaneous melanoma incidence ( J:98545 )

• 17 of 18 mice develop cutaneous melanomas within 6 months of birth

• melanomas present as black and frequently ulcerated nodules that are found in the trunk (in 81% of mice), upper and lower extremities (in 22% of mice), and head and neck (in 39% of mice)

• acral melanomas and melanomas of the genitalia are present in a few mice

• melanomas are predominantly melanotic and epitheloid containing numerous macrophages and are vascularized

• in some tumors, atypical melanocytes are found un the surface or adnexal epithelium

• in some mice tumors are present within a rather hyperplastic epidermis or at the epidermal/dermal junction of hair follicle

• only 10% to 50% of tumor cells express nestin indicating that melanomas are comprised of at least two subpopulations

increased metastatic potential ( J:98545 )

• melanomas metastasize to the liver and lung in 36% of mice

immune system

enlarged lymph nodes ( J:98545 )

• 64% of tumor-bearing mice exhibit enlarged lymph nodes

integument

increased cutaneous melanoma incidence ( J:98545 )

• 17 of 18 mice develop cutaneous melanomas within 6 months of birth

• melanomas present as black and frequently ulcerated nodules that are found in the trunk (in 81% of mice), upper and lower extremities (in 22% of mice), and head and neck (in 39% of mice)

• acral melanomas and melanomas of the genitalia are present in a few mice

• melanomas are predominantly melanotic and epitheloid containing numerous macrophages and are vascularized

• in some tumors, atypical melanocytes are found un the surface or adnexal epithelium

• in some mice tumors are present within a rather hyperplastic epidermis or at the epidermal/dermal junction of hair follicle

• only 10% to 50% of tumor cells express nestin indicating that melanomas are comprised of at least two subpopulations

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin melanoma		DOID:8923	OMIM:608035 OMIM:612263	J:98545

Allelic Composition	Cdkn2a^tm1Rdp/Cdkn2a^tm1Rdp Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: 129/Sv * C57BL/6J * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Rdp mutation (6 available); any Cdkn2a mutation (62 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

skin lesions ( J:193443 )

• dermal lesions that resemble giant congenital naevi

increased cutaneous melanoma incidence ( J:193443 )

• 100% of mutants develop melanoma by 6 months of age

pigmentation

hyperpigmentation ( J:193443 )

• hyperpigmentation of the naevus nests close to the epidermis and naevus cells around and within hair follicles and other adnexal structures such as sebaceous glands

• skin hyperpigmentation is apparent at the first postnatal week and is restricted to the dermis

neoplasm

increased cutaneous melanoma incidence ( J:193443 )

• 100% of mutants develop melanoma by 6 months of age

Allelic Composition	Tg(Tyr-DT)3Bee/? Tg(Tyr-NRAS*Q61K)1Bee/?
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-DT)3Bee mutation (0 available)
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:98545 )

• mice seem normal and have normal skin

Allelic Composition	Tg(Tyr-NRAS*Q61K)1Bee/0
Genetic Background	involves: C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal melanocyte proliferation ( J:193443 )

• increase in the number of proliferative Dct+ cells localized to hair follicles

integument

skin lesions ( J:193443 )

• dermal lesions that resemble giant congenital naevi

pigmentation

abnormal melanocyte proliferation ( J:193443 )

• increase in the number of proliferative Dct+ cells localized to hair follicles

Allelic Composition	Tg(Tyr-NRAS*Q61K)1Bee/?
Genetic Background	involves: BALB/c * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

skin inflammation ( J:98545 )

integument

skin inflammation ( J:98545 )

abnormal hair follicle morphology ( J:98545 )

• hair follicle architecture is disrupted

epidermal hyperplasia ( J:98545 )

Allelic Composition	Tg(Tyr-NRAS*Q61K)1Bee/?
Genetic Background	involves: C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Tyr-NRAS*Q61K)1Bee mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

abnormal melanocyte morphology ( J:98545 )

• melanocytes in the papillary dermis while few melanocytes are found within the interfollicular epidermis and the hair follicles

hyperpigmentation ( J:98545 )

• mice exhibit hyperpigmentation of the skin, paws, ears and tail

• mice exhibit a band-like distribution of pigmented

vision/eye

abnormal optic choroid morphology ( J:98545 )

• the choroidal layer is thickened resulting in a folding of the neuroretina in adult mice

immune system

skin inflammation ( J:98545 )

integument

skin inflammation ( J:98545 )

abnormal hair follicle morphology ( J:98545 )

• hair follicle architecture is occasionally disrupted

• numerous melanocytes are found in the epithelium of the upper, permanent, portion of the hair follicle and seem to disrupt follicles during anagen

abnormal dermis papillary layer morphology ( J:98545 )

• melanocytes are present in the papillary dermis

abnormal dermis reticular layer morphology ( J:98545 )

• melanin-containing macrophages are found within the reticular dermis and subcutaneous fat

hyperkeratosis ( J:98545 )

• in some mice

epidermal hyperplasia ( J:98545 )

• in some mice

thick epidermis ( J:98545 )

• in some mice

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