Sox10tm7.1(Sox10)Weg
Targeted Allele Detail
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Symbol: |
Sox10tm7.1(Sox10)Weg |
Name: |
SRY (sex determining region Y)-box 10; targeted mutation 7.1, Michael Wegner |
MGI ID: |
MGI:4820417 |
Synonyms: |
Sox10fl |
Gene: |
Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
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Alliance: |
Sox10tm7.1(Sox10)Weg page
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Germline Transmission: |
Earliest citation of germline transmission:
J:162692
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site was inserted upstream of exon 3. The coding region was replaced with a cDNA of the rat homolog, a floxed and FRT flanked neo cassette, and an IRES-EGFP-pA cassette. Flp mediated recombination removed the neo cassette leaving the the rat cDNA floxed and the reporter cassette intact.
(J:162692)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Sox10 Mutation: |
33 strains or lines available
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Original: |
J:162692 Finzsch M, et al., Sox10 is required for Schwann cell identity and progression beyond the immature Schwann cell stage. J Cell Biol. 2010 May 17;189(4):701-12 |
All: |
20 reference(s) |
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