Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Asin mutation
(0 available);
any
Cd8a mutation
(36 available)
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immune system
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• surface expression of CD5 is 1.7 fold higher than WT double positive thymocytes, indicating increased TCR signaling strength in the mutant mice
• there is an increased influx of calcium upon stimulation with anti-CD8 and anti-TCRbeta antibodies, indicating increased TCR signaling strength
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hematopoietic system
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• surface expression of CD5 is 1.7 fold higher than WT double positive thymocytes, indicating increased TCR signaling strength in the mutant mice
• there is an increased influx of calcium upon stimulation with anti-CD8 and anti-TCRbeta antibodies, indicating increased TCR signaling strength
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Allelic
Composition |
Cd8atm1Asin/Cd8atm1Mak
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Genetic
Background |
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Asin mutation
(0 available);
any
Cd8a mutation
(36 available)
Cd8atm1Mak mutation
(7 available);
any
Cd8a mutation
(36 available)
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immune system
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• the conversion of double positive T cells into single-positive CD8 T cells is 2.5 fold greater than in wild-type littermates
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• the ratio of CD4/CD8 T cells in the thymus, spleen, and lymph nodes is reversed from 1.5 to 0.5
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• absolute numbers of mature CD8-positive T cell are about 2 fold higher in the spleen, lymph nodes, and thymus
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hematopoietic system
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• the conversion of double positive T cells into single-positive CD8 T cells is 2.5 fold greater than in wild-type littermates
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• the ratio of CD4/CD8 T cells in the thymus, spleen, and lymph nodes is reversed from 1.5 to 0.5
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• absolute numbers of mature CD8-positive T cell are about 2 fold higher in the spleen, lymph nodes, and thymus
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immune system
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• these cells are almost absent in the thymus and the lymph nodes
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• 1.6 fold increase in number of these cells in the lymph nodes, compared to mice that have a wild-type allele for Cd8a on this mutant background
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hematopoietic system
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• these cells are almost absent in the thymus and the lymph nodes
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• 1.6 fold increase in number of these cells in the lymph nodes, compared to mice that have a wild-type allele for Cd8a on this mutant background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Asin mutation
(0 available);
any
Cd8a mutation
(36 available)
Tg(CD2-TcraF5,CD2-TcrbF5)1Kio mutation
(0 available)
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immune system
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• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice
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• these cells are almost absent in the thymus and the lymph nodes
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• the number of CD8-positive T cells that express the transgenic TCR is significantly higher compared to transgenic mice that have wild-type CD8 alleles
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hematopoietic system
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• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice
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• these cells are almost absent in the thymus and the lymph nodes
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• the number of CD8-positive T cells that express the transgenic TCR is significantly higher compared to transgenic mice that have wild-type CD8 alleles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd8atm1Asin mutation
(0 available);
any
Cd8a mutation
(36 available)
Rag2tm1Fwa mutation
(48 available);
any
Rag2 mutation
(117 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation
(3 available)
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immune system
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• CD8 expression on T cells from female mice is lower compared to T cells from female mutant mice that have wild-type Cd8a alleles
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hematopoietic system
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• CD8 expression on T cells from female mice is lower compared to T cells from female mutant mice that have wild-type Cd8a alleles
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Analysis Tools