Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pggt1btm1.1Mbrg mutation
(0 available);
any
Pggt1b mutation
(25 available)
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cellular
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• cells isolated from an embryo are small and spindle shaped with a dramatic reduction in the amount of polymerized actin
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• cell migration in a wound healing assay was reduced by 60%-80%
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation
(0 available);
any
Fntb mutation
(207 available)
Fntbtm1.2Mbrg mutation
(0 available);
any
Fntb mutation
(207 available)
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Pggt1btm1.1Mbrg mutation
(0 available);
any
Pggt1b mutation
(25 available)
Pggt1btm1Mbrg mutation
(0 available);
any
Pggt1b mutation
(25 available)
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mortality/aging
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• median life span is 170 days
• longer median life span than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice (170 vs. 22 days)
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neoplasm
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• lung weight and histology are indistinguishable from littermate control mice at 3-week old, compare with lung weight is 10-fold higher in Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice
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• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age
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respiratory system
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• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation
(0 available);
any
Fntb mutation
(207 available)
Fntbtm1.2Mbrg mutation
(0 available);
any
Fntb mutation
(207 available)
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Pggt1btm1.1Mbrg mutation
(0 available);
any
Pggt1b mutation
(25 available)
Pggt1btm1Mbrg mutation
(0 available);
any
Pggt1b mutation
(25 available)
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neoplasm
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• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
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• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
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• presence of small adenomas after Cre-adenovirus treatment
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• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment
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respiratory system
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• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
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• presence of small adenomas after Cre-adenovirus treatment
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• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment
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• presence of epithelial hyperplasia after Cre-adenovirus treatment
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