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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pggt1btm1Mbrg
targeted mutation 1, Martin O Bergo
MGI:3713756
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pggt1btm1Mbrg/Pggt1btm1Mbrg involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3714150
cn2
 		Pggt1btm1Mbrg/Pggt1btm1Mbrg
Krastm4Tyj/Kras+ 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3714152
cn3
 		Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3714153
cn4
 		Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1b+
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129/Sv * 129P2/OlaHsd * C57BL/6 MGI:3714154
cn5
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441488
cn6
 		Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg 		involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N MGI:4441490
cn7
 		Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg 		involves: 129P2/OlaHsd * C57BL/6 MGI:4441487
cn8
 		Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4442806
cn9
 		Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/? 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:4442843


Genotype
MGI:3714150
cn1
Allelic
Composition		 Pggt1btm1Mbrg/Pggt1btm1Mbrg
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
absent fibroblast proliferation ( J:122107 )
• following Cre-adenovirus treatment, embryonic fibroblast proliferation is arrested irreversibly
• however, cell viability is unaffected




Genotype
MGI:3714152
cn2
Allelic
Composition		 Pggt1btm1Mbrg/Pggt1btm1Mbrg
Krastm4Tyj/Kras+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell morphology ( J:122107 )
• cre-activation leads to a rounded cell shape
• however, farnesylation of RHOA and CDC42 restores normal cell shape
decreased cell proliferation ( J:122107 )
• cre-activation leads to decreased cell proliferation
• however, farnesylation of RHOA and CDC42 restores proliferation induced by Krastm4Tyj




Genotype
MGI:3714153
cn3
Allelic
Composition		 Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:122107 )
• mice survive longer than Pggt1btm1Mbrg Lyzstm1(cre)Ifo Krastm4Tyj heterozygotes with some surviving until day 98 when they were euthanized

neoplasm
increased lung tumor incidence ( J:122107 )
• few, very mild adenomatous hyperplasia are present at day 11 and increase in occurence by day 62
• however, many segments of the lung are normal at day 62
increased lung adenoma incidence ( J:122107 )
• at day 98, progressed and scattered adenomas are present

respiratory system
increased lung weight ( J:122107 )
• lung weight is less than in Pggt1btm1Mbrg Lyzstm1(cre)Ifo Krastm4Tyj heterozygotes but higher than in normal mice
increased lung tumor incidence ( J:122107 )
• few, very mild adenomatous hyperplasia are present at day 11 and increase in occurence by day 62
• however, many segments of the lung are normal at day 62
increased lung adenoma incidence ( J:122107 )
• at day 98, progressed and scattered adenomas are present

growth/size/body
postnatal growth retardation ( J:122107 )
• after day 40, mice grow slower than controls
• however, up to day 40 mice grow normally
increased lung weight ( J:122107 )
• lung weight is less than in Pggt1btm1Mbrg Lyzstm1(cre)Ifo Krastm4Tyj heterozygotes but higher than in normal mice




Genotype
MGI:3714154
cn4
Allelic
Composition		 Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1b+
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:122107 )
• mice are normal until day 17 when they begin to die or must be euthanized median survival is to day 20

neoplasm
increased lung tumor incidence ( J:122107 )
• tumors range from atypical adenomatous hyperplasia, adenoma and adenocarcinoma at day 11 to diffuse adenocarsinoma that obliterate alveolar space by day 20
increased lung adenocarcinoma incidence ( J:122107 )
• beginning at day 11 and obliterating alveolar space by day 20

respiratory system
increased lung weight ( J:122107 )
• lung weight increases 10-fold between day 18 and 22
increased lung tumor incidence ( J:122107 )
• tumors range from atypical adenomatous hyperplasia, adenoma and adenocarcinoma at day 11 to diffuse adenocarsinoma that obliterate alveolar space by day 20
increased lung adenocarcinoma incidence ( J:122107 )
• beginning at day 11 and obliterating alveolar space by day 20
respiratory distress ( J:122107 )
• after day 17

immune system
increased neutrophil cell number ( J:122107 )
• percentage of neutrophil is higher in peripheral blood than in controls
decreased lymphocyte cell number ( J:122107 )
• percentage of lymphocytes is lower than in controls
abnormal spleen morphology ( J:122107 )
• pools of immature myeloid are present in the spleen

hematopoietic system
abnormal definitive hematopoiesis ( J:122107 )
• pools of immature myeloid are present in the spleen
• myeloid proliferation is increased
increased neutrophil cell number ( J:122107 )
• percentage of neutrophil is higher in peripheral blood than in controls
decreased lymphocyte cell number ( J:122107 )
• percentage of lymphocytes is lower than in controls
abnormal spleen morphology ( J:122107 )
• pools of immature myeloid are present in the spleen

liver/biliary system
abnormal liver morphology ( J:122107 )
• myeloid infiltration of the liver occurs

growth/size/body
weight loss ( J:122107 )
• after day 17
increased lung weight ( J:122107 )
• lung weight increases 10-fold between day 18 and 22




Genotype
MGI:4441488
cn5
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (207 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:158937 )
• median life span is 170 days
• longer median life span than Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice (170 vs. 22 days)

neoplasm
decreased tumor growth/size ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old, compare with lung weight is 10-fold higher in Lyz2tm1(cre)Ifo, Krastm4Tyj heterozygous mice
increased lung tumor incidence ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age

respiratory system
increased lung tumor incidence ( J:158937 )
• lung weight and histology are indistinguishable from littermate control mice at 3-week old
• but eventually develop lung tumors at older age




Genotype
MGI:4441490
cn6
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.2Mbrg
Krastm4Tyj/Kras+
Pggt1btm1Mbrg/Pggt1btm1.1Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * BALB/cJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Fntbtm1.2Mbrg mutation (0 available); any Fntb mutation (207 available)
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Pggt1btm1.1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased tumor growth/size ( J:158937 )
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung tumor incidence ( J:158937 )
• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung adenoma incidence ( J:158937 )
• presence of small adenomas after Cre-adenovirus treatment
increased lung carcinoma incidence ( J:158937 )
• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment

respiratory system
increased lung tumor incidence ( J:158937 )
• the lung surface of Cre-adenovirus treated mice is nearly indistinguishable from that of control mice
• 76% fewer tumors and 79% smaller lesion area than Krastm4Tyj heterozygous mice after Cre-adenovirus treatment
increased lung adenoma incidence ( J:158937 )
• presence of small adenomas after Cre-adenovirus treatment
increased lung carcinoma incidence ( J:158937 )
• adenocarcinoma in 1 of 11 mice after Cre-adenovirus treatment
abnormal lung epithelium morphology ( J:158937 )
• presence of epithelial hyperplasia after Cre-adenovirus treatment




Genotype
MGI:4441487
cn7
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast apoptosis ( J:158937 )
• Cre-adenovirus treatment results in apoptosis in embryonic fibroblasts within 4 days
• Cre-adenovirus treatment results in apoptosis in embryonic fibroblasts expressing oncogenic H-RAS in the plasma membrane




Genotype
MGI:4442806
cn8
Allelic
Composition		 Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:158528 )
• die within a few hours of birth with little milk in their stomachs

integument
decreased keratinocyte proliferation ( J:158528 )
• epidermal keratinocytes do not proliferate in culture
underdeveloped hair follicles ( J:158528 )
• E19.5 embryos have stunted hair follicles

cellular
decreased keratinocyte proliferation ( J:158528 )
• epidermal keratinocytes do not proliferate in culture




Genotype
MGI:4442843
cn9
Allelic
Composition		 Fntbtm1.1Mbrg/Fntbtm1.1Mbrg
Pggt1btm1Mbrg/Pggt1btm1Mbrg
Tg(KRT14-cre)1Amc/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntbtm1.1Mbrg mutation (0 available); any Fntb mutation (207 available)
Pggt1btm1Mbrg mutation (0 available); any Pggt1b mutation (25 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
decreased hair follicle number ( J:158528 )
• at E17.5 embryos have fewer hair follicles
thin epidermis ( J:158528 )
• interfollicular epidermis is slightly thinner compared to either single mutant at E17.5
abnormal skin physiology ( J:158528 )
• at E17.5 more apoptotic cells are present than in either single mutant




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory