All Phenotypes Mapk1<tm1Hed> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mapk1^tm1Hed
targeted mutation 1, Stephen M Hedrick
MGI:3686887

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Lck-cre)1Cwi/0	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3687234
cn2	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0	involves: 129/Sv * C57BL/6 * DBA/2	MGI:3687236
cn3	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0 Tg(TcrAND)53Hed/0	involves: 129/Sv * C57BL/6 * DBA/2 * SJL	MGI:3687238
cn4	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Lck-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:3687232
cn5	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Cd4-cre)1Cwi/0	involves: C57BL/6 * DBA/2	MGI:3687235
cn6	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Lck-cre)1Cwi/0 Tg(TcrAND)53Hed/0	involves: C57BL/6 * DBA/2 * SJL	MGI:3687239
cx7	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(TcraTcrb)1100Mjb/0	involves: 129/Sv * C57BL/6	MGI:3687241
cx8	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(TcraTcrb)1100Mjb/0	involves: C57BL/6	MGI:3687240
cx9	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(TcrAND)53Hed/0	involves: C57BL/6 * DBA/2 * SJL	MGI:3687237

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (40 available)
Mapk3^tm1Gpg mutation (1 available); any Mapk3 mutation (26 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

small thymus ( J:113280 )

• some mice have very small thymuses (13 x 10⁶ cells) with few DN4 cells, but some have larger thymuses (115 x 10⁶ cells)

decreased thymocyte number ( J:113280 )

• total thymocyte number is decreased >3-fold compared to wild-type

increased double-positive T cell number ( J:113280 )

• mice have a substantial population of double-positive T cells

hematopoietic system

abnormal T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

small thymus ( J:113280 )

• some mice have very small thymuses (13 x 10⁶ cells) with few DN4 cells, but some have larger thymuses (115 x 10⁶ cells)

decreased thymocyte number ( J:113280 )

• total thymocyte number is decreased >3-fold compared to wild-type

increased double-positive T cell number ( J:113280 )

• mice have a substantial population of double-positive T cells

endocrine/exocrine glands

small thymus ( J:113280 )

• some mice have very small thymuses (13 x 10⁶ cells) with few DN4 cells, but some have larger thymuses (115 x 10⁶ cells)

decreased thymocyte number ( J:113280 )

• total thymocyte number is decreased >3-fold compared to wild-type

cellular

abnormal T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes but there is still a substantial population of single positive thymocytes

immune system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes but there is still a substantial population of single positive thymocytes

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(Cd4-cre)1Cwi/0 Tg(TcrAND)53Hed/0
Genetic Background	involves: 129/Sv * C57BL/6 * DBA/2 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:113280 )

• positive selection is diminished significantly

abnormal T cell subpopulation ratio ( J:113280 )

• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 24 compared to 257 in non transgenic littermates

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• positive selection is diminished significantly

abnormal T cell subpopulation ratio ( J:113280 )

• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 24 compared to 257 in non transgenic littermates

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Lck-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (40 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

decreased double-positive T cell number ( J:113280 )

• total number of double-positive (DP) thymocytes is reduced by 30%

abnormal T cell subpopulation ratio ( J:113280 )

• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation

hematopoietic system

decreased T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

decreased double-positive T cell number ( J:113280 )

• total number of double-positive (DP) thymocytes is reduced by 30%

abnormal T cell subpopulation ratio ( J:113280 )

• there is a substantial increase in number of DN3 thymocytes over DN4, consistent with partial block in maturation

cellular

decreased T cell proliferation ( J:113280 )

• thymocytes display normal or slightly enhanced proliferation in vivo

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (40 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes

increased double-positive T cell number ( J:113280 )

• increase in double positive thymocytes and compensatory decrease in single positive numbers restores thymic cellularity compare to Mapk1/Lck-cre transgenics

decreased CD4-positive, alpha-beta T cell number ( J:113280 )

• number of CD4 single positive thymocytes is decreased compared to wild-type

decreased CD8-positive, alpha-beta T cell number ( J:113280 )

• number of CD8 single positive thymocytes is decreased compared to wild-type

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• there is a significant reduction in percentage of positively-selected thymocytes

increased double-positive T cell number ( J:113280 )

• increase in double positive thymocytes and compensatory decrease in single positive numbers restores thymic cellularity compare to Mapk1/Lck-cre transgenics

decreased CD4-positive, alpha-beta T cell number ( J:113280 )

• number of CD4 single positive thymocytes is decreased compared to wild-type

decreased CD8-positive, alpha-beta T cell number ( J:113280 )

• number of CD8 single positive thymocytes is decreased compared to wild-type

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(Lck-cre)1Cwi/0 Tg(TcrAND)53Hed/0
Genetic Background	involves: C57BL/6 * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (40 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:113280 )

• positive selection is diminished significantly

abnormal T cell subpopulation ratio ( J:113280 )

• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 20 compared to 257 in non transgenic littermates

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• positive selection is diminished significantly

abnormal T cell subpopulation ratio ( J:113280 )

• CD4 to CD8 ratio (% of mature CD4 and CD8 T cells) is 20 compared to 257 in non transgenic littermates

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Mapk3^tm1Gpg/Mapk3^tm1Gpg Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

hematopoietic system

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

endocrine/exocrine glands

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (40 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

hematopoietic system

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

endocrine/exocrine glands

decreased thymocyte number ( J:113280 )

• population is lower than in Mapk1-deficient mice with Tg(CD4-cre)1Cwi or with transgene and Mapk3 deficiency

Allelic Composition	Mapk1^tm1Hed/Mapk1^tm1Hed Tg(TcrAND)53Hed/0
Genetic Background	involves: C57BL/6 * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1^tm1Hed mutation (0 available); any Mapk1 mutation (40 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:113280 )

• reduction in TCRhi, CD69hi and CD69lo indicate inefficient positive selection

abnormal double-positive T cell morphology ( J:113280 )

• mice show altered proportion of double positive and CD4 populations

hematopoietic system

abnormal positive T cell selection ( J:113280 )

• reduction in TCRhi, CD69hi and CD69lo indicate inefficient positive selection

abnormal double-positive T cell morphology ( J:113280 )

• mice show altered proportion of double positive and CD4 populations

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