Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch2tm1Pmc mutation
(0 available);
any
Ptch2 mutation
(47 available)
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normal phenotype
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• mutants are viable and apparently normal; no differences are observed in cell proliferation or differentiation in the cerebellum
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neoplasm
N |
• mice show no increase in tumor incidence compared to Ptch1/Trp53 double null mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch2tm1Pmc mutation
(0 available);
any
Ptch2 mutation
(47 available)
Trp53tm1Tyj mutation
(12 available);
any
Trp53 mutation
(232 available)
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neoplasm
N |
• double mutants show similar tumor profile and latency as Trp53-null animals (11/20 develop thymoma and/or sarcoma by 4 months of age)
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Allelic Composition |
Ptch1tm1Mps/Ptch1+ Ptch2tm1Pmc/Ptch2+
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Genetic Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation
(2 available);
any
Ptch1 mutation
(115 available)
Ptch2tm1Pmc mutation
(0 available);
any
Ptch2 mutation
(47 available)
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neoplasm
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• 2/54 males develop testicular teratomas
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• frequency is greater (3/63) compared to Ptch1-deficient mice (1/62)
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• incidence is increased in frequency
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• 50% develop tumors by 5 months of age, compared to ~15% of Ptch1-heterozygous, Ptch2-sufficient mice develop tumors by 12 months of age
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cardiovascular system
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• subcutaneous telangiectasia is observed in 2% of mice
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digestive/alimentary system
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• ~19% of mice display intestinal serosal angiectasis
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muscle
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• subcutaneous telangiectasia is observed in 2% of mice
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• incidence is increased in frequency
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integument
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• frequency is greater (3/63) compared to Ptch1-deficient mice (1/62)
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endocrine/exocrine glands
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• 2/54 males develop testicular teratomas
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reproductive system
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• 2/54 males develop testicular teratomas
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptch1tm1Mps mutation
(2 available);
any
Ptch1 mutation
(115 available)
Ptch2tm1Pmc mutation
(0 available);
any
Ptch2 mutation
(47 available)
|
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neoplasm
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• increased tumorigenesis is readily apparent in 6th-generation compound mutants
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• frequency is greater (5/97) compared to Ptch1-deficient mice (1/62)
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• incidence is increased in frequency
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• occur with higher frequency
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• 50% develop tumors by 10 months of age, compared to ~15% of Ptch1-heterozygous, Ptch2-sufficient mice develop tumors by 12 months of age
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digestive/alimentary system
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• ~18% of mice display intestinal serosal angiectasis
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integument
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• frequency is greater (5/97) compared to Ptch1-deficient mice (1/62)
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nervous system
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• occur with higher frequency
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muscle
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• incidence is increased in frequency
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