Phenotypes associated with this allele

• Allele Symbol: Tg(KRT5-CDK4)2303Mlrp
• Allele Name: transgene insertion 2303, Marcelo L Rodriguez-Puebla
• Allele ID: MGI:3624634
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Tg(KRT5-CDK4)2303Mlrp/0	involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN	MGI:3624687
tg2	Tg(KRT5-CDK4)2303Mlrp/0	involves: FVB * SSIN	MGI:3624695

Genotype
MGI:3624687

cx1

• Allelic Composition: Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf; Tg(KRT5-CDK4)2303Mlrp/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB * SENCAR * SSIN

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

enlarged thymus ( J:107588 )

• mutants have increased thymic lymphocyte cellularity

thymus hyperplasia ( J:107588 )

• mutants develop massive thymic hyperplasia; thymuses are 4-fold larger than those of Cdkn1b-null mice and 6-fold larger than Cdk4-deficient mice

hematopoietic system

enlarged thymus ( J:107588 )

• mutants have increased thymic lymphocyte cellularity

thymus hyperplasia ( J:107588 )

• mutants develop massive thymic hyperplasia; thymuses are 4-fold larger than those of Cdkn1b-null mice and 6-fold larger than Cdk4-deficient mice

endocrine/exocrine glands

enlarged thymus ( J:107588 )

• mutants have increased thymic lymphocyte cellularity

thymus hyperplasia ( J:107588 )

• mutants develop massive thymic hyperplasia; thymuses are 4-fold larger than those of Cdkn1b-null mice and 6-fold larger than Cdk4-deficient mice

Genotype
MGI:3624695

tg2

• Allelic Composition: Tg(KRT5-CDK4)2303Mlrp/0
• Genetic Background: involves: FVB * SSIN

cellular

abnormal cell morphology ( J:108690 )

• cells in the interfollicular epidermis and the hair follicles of transgenics show an increase in the size of the nucleus compared to wild-type littermates

integument

abnormal dermal layer morphology ( J:108690 )

• dermal fibrosis with severe hypoplasia of the subcutaneous adipose tissue is observed

thick dermal layer ( J:108690 )

• thickness of dermal layer is increased 2.8-fold in transgenics over wild-type

abnormal epidermis stratum basale morphology ( J:108690 )

• number of proliferating cells in epidermis of transgenic mice is 4-fold higher compared to wild-type

abnormal epidermis stratum granulosum morphology ( J:108690 )

• layer is significantly increased compared to granule layer in wild-type

abnormal epidermis stratum spinosum morphology ( J:108690 )

• layer is significantly increased compared to spinous layer in wild-type

thick epidermis ( J:108690 )

• epidermis is hyperplastic; average thickness of the epidermis of transgenic mice is 2-fold greater than in wild-type