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Allele Symbol Allele Name Allele ID |
Lcp2tm2Gak targeted mutation 2, Gary A Koretzky MGI:3623388 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• at E14.5, mice exhibit blood-filled cutaneous lymphatics unlike in wild-type mice
• neonates exhibit blood-filled mesenteric lymphatics unlike in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some mice exhibit blood-filled Peyer patches unlike in wild-type mice
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• mice exhibit blood-filled mesenteric and intestinal lymphatic vessels unlike wild-type mice
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• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells
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• platelets from neonates without vascular phenotypes exhibit intermediate levels of convulxin-stimulated fibrinogen binding compared with similarly treated wild-type cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• stimulation of cultured thymocytes with anti-CD3 or combination of anti-CD3 and anti-CD28 does not result in increased cell death of double positive T cells from mutant mice like treatment induces in thymocytes from wild-type mice
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• there is a significant reduction in CD4+ and mature CD8+ thymocyte numbers in adult mutant mice but absolute cellularity doesn't differ between mutants and wild-type mice
• thymic cellularity in 5 week-old mice is reduced by around 50%; absolute cellularity of double positive, CD4+ and CD8+ cells is reduced significantly
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• there is a dramatic reduction in percentage of CD4+ thymocytes to less than 1% of the thymic cell population compared to that of wild-type littermates
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• relative percentage of CD8+ thymocytes is reduced by 40-60% of that in wild-type littermates
• most of the cells in the CD8+ compartment in mutants are immature compared to cells in the wild-type
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• mutant mice have about 2-fold more gamma delta T cells compared to 5 week-old control littermates
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• stimulation of cultured thymocytes with anti-CD3 or combination of anti-CD3 and anti-CD28 does not result in increased cell death of double positive T cells from mutant mice like treatment induces in thymocytes from wild-type mice
|
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• there is a significant reduction in CD4+ and mature CD8+ thymocyte numbers in adult mutant mice but absolute cellularity doesn't differ between mutants and wild-type mice
• thymic cellularity in 5 week-old mice is reduced by around 50%; absolute cellularity of double positive, CD4+ and CD8+ cells is reduced significantly
|
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• there is a dramatic reduction in percentage of CD4+ thymocytes to less than 1% of the thymic cell population compared to that of wild-type littermates
|
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• relative percentage of CD8+ thymocytes is reduced by 40-60% of that in wild-type littermates
• most of the cells in the CD8+ compartment in mutants are immature compared to cells in the wild-type
|
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• mutant mice have about 2-fold more gamma delta T cells compared to 5 week-old control littermates
|
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• stimulation of cultured thymocytes with anti-CD3 or combination of anti-CD3 and anti-CD28 does not result in increased cell death of double positive T cells from mutant mice like treatment induces in thymocytes from wild-type mice
|
|
• there is a significant reduction in CD4+ and mature CD8+ thymocyte numbers in adult mutant mice but absolute cellularity doesn't differ between mutants and wild-type mice
• thymic cellularity in 5 week-old mice is reduced by around 50%; absolute cellularity of double positive, CD4+ and CD8+ cells is reduced significantly
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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