Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm2Mak mutation
(4 available);
any
Pten mutation
(81 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
Tg(Myh6-Pik3ca)1Siz mutation
(0 available)
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cardiovascular system
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• display a reduction in heart size similar to that seen in single Tg(Myh6-Pik3ca)1Siz mice
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muscle
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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growth/size/body
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• heart weight/body weight ratio is increased to a similar extent as in single Tg(Myh6-Pik3r1/PIK3CA)BSiz mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• the heart weight/body weight ratio is significantly lower than in single Tg(Myh6-IGF1R)7Siz mice and not different from single Tg(Myh6-Pik3ca)1Siz mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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growth/size/body
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• the heart weight/body weight ratio is similar to that of single Tg(Myh6-Akt1*T308D*S473D)1Siz mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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mortality/aging
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• mice exhibit shortened lifespan compared to single Tg(Myh6-cre)TG9Pjay transgenic mice
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cardiovascular system
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• mice exhibit accelerated progression of heart failure compared to single Tg(Myh6-cre)TG9Pjay transgenic mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• myocytes exhibit an 18% decrease in mean cell size, with both the long and short axis lengths decreased
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• heart weight/body weight ratio is decreased by 17% without changes in the size of other organs or overall body weight, however show no signs of heart failure or abnormal cardiac function after 1 year
(J:62707)
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• mice subjected to pressure overload with aortic banding exhibit an increase in left ventricle end-systolic and diastolic volumes and depressed systolic function, exaggerated cardiac hypertrophy, increased left ventricle chamber dimension, and increased cardiac fibrosis in the left ventricular wall
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homeostasis/metabolism
muscle
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• myocytes exhibit an 18% decrease in mean cell size, with both the long and short axis lengths decreased
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Analysis Tools