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Tg(Myh6-cre)TG9Pjay
Transgene Detail
Summary
Symbol: Tg(Myh6-cre)TG9Pjay
Name: transgene insertion TG9, Patrick Y Jay
MGI ID: MGI:5496902
Synonyms: DCM-TG9, TG 9
Transgene: Tg(Myh6-cre)TG9Pjay  Location: unknown  
Alliance: Tg(Myh6-cre)TG9Pjay page
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailscDNA encoding cre recombinase was cloned into a vector containing a 5.8 kb fragment of the Myh6 (alpha-MHC) promoter including the promoter region and exons 1-3 with the hGH polyadenylation site 3' to the Myh6 fragment. The purified construct was microinjected into male pronuclei of fertilized FVB/N oocytes. 6 founders died with signs of congestive heart failure before germline transmission was established. Two founders transmitted the transgene to produce lines TG 9 and TG 12. TG9 mice developed severe cardiomyopathy and died of heart failure at 11-13 weeks. TG12 animals did not show any pathological cardiac phenotype. The TG9 line was investigated in detail. TG9 cre protein levels are much higher than in TG12 animals, and 50-100 fold higher than in Tg(Myhca-cre)1Abel mice. (J:198043)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Myh6 (species not specified)
Summary of all recombinase alleles driven by Myh6.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:198043 Buerger A, et al., Dilated cardiomyopathy resulting from high-level myocardial expression of Cre-recombinase. J Card Fail. 2006 Jun;12(5):392-8
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory