All Phenotypes TgTn(sb-T2/Onc)68Dla MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

TgTn(sb-T2/Onc)68Dla
transgenic transposon concatemer 68, David A Largaespada
MGI:3612984

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Trp53^tm3Tyj/Trp53⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:3839859
cn2	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839797
cn3	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839857
cx4	Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0	FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1^{Tg(CAG-sb10)1Dla}	MGI:3613026
cx5	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0	involves: 129X1/SvJ * FVB/N	MGI:3613024

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Trp53^tm3Tyj/Trp53⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(sb11)Njen} mutation (7 available); any Gt(ROSA)26Sor mutation (944 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

• liver nodules in quadruple transgenic mice are larger and more numerous compared to triple transgenic mice that are wild-type at the Trp53 locus

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Allelic Composition	Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	FVB/N-TgTn(sb-T2/Onc)68Dla Sclt1^{Tg(CAG-sb10)1Dla}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sclt1^{Tg(CAG-sb10)1Dla} mutation (1 available); any Sclt1 mutation (38 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:99991 )

N	• up to 1 year of age no signs of increased tumor susceptibility are seen

Allelic Composition	Cdkn2a^tm1Cjs/Cdkn2a^tm1Cjs Sclt1^{Tg(CAG-sb10)1Dla}/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm1Cjs mutation (6 available); any Cdkn2a mutation (62 available)
Sclt1^{Tg(CAG-sb10)1Dla} mutation (1 available); any Sclt1 mutation (38 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:99991 )

• mice died earlier than those homozygous for Cdkn2a^tm1Cjs alone

neoplasm

increased tumor incidence ( J:99991 )

• tumor spectrum was similar to Cdkn2a^tm1Cjs homozygotes and included malignant meningiomas

increased leukemia incidence ( J:99991 )

• myeloid leukemias were seen

increased lymphoma incidence ( J:99991 )

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

increased sarcoma incidence ( J:99991 )

• soft tissue sarcomas or osteosarcomas

increased osteosarcoma incidence ( J:99991 )

respiratory system

increased lung adenocarcinoma incidence ( J:99991 )

• a pulmonary adenocarcinoma was seen

skeleton

increased osteosarcoma incidence ( J:99991 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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