Sclt1^{Tg(CAG-sb10)1Dla}
Transgenic Allele Detail

Summary

• Symbol: Sclt1^{Tg(CAG-sb10)1Dla}
• Name: sodium channel and clathrin linker 1; transgene insertion 1, David A Largaespada
• MGI ID: MGI:3612989
• Synonyms: CAGGS-SB10, Tg(ACTB-sb10)1Dla, Tg(CAG-sb10)1Dla
• Gene: Sclt1 Location: Chr3:41581155-41696949 bp, - strand Genetic Position: Chr3, 19.91 cM, cytoband C
• Alliance: Sclt1^{Tg(CAG-sb10)1Dla} page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Null/knockout, Transposase)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The ubiquitously expressed CAGGS chimeric promoter derived from chicken beta-actin and CMV immediate early promoter sequences drives expression of the sleeping beauty 10 (sb10) transposase. The transgene caused a 3 kb deletion in and inserted into intron 12 of the host gene. RNA-seq confirmed the absence of transcription from exons 13 onward. (J:70414)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Sclt1^{Tg(CAG-sb10)1Dla}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sclt1 Mutation: 38 strains or lines available

References

• Original: J:70414 Dupuy AJ, et al., Transposition and gene disruption in the male germline of the mouse. Genesis. 2001 Jun;30(2):82-8
• All: 11 reference(s)