All Phenotypes Ino80<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ino80⁺
wild type
MGI:3610367

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ino80^{tm1a(EUCOMM)Hmgu}/Ino80⁺	C57BL/6N-Ino80^{tm1a(EUCOMM)Hmgu}/Ics	MGI:5757252
ht2	Ino80^tm1.1Schg/Ino80⁺	involves: C57BL/6J	MGI:5898011
cx3	Ino80^tm1.1Schg/Ino80⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6J	MGI:5898013

Allelic Composition	Ino80^{tm1a(EUCOMM)Hmgu}/Ino80⁺
Genetic Background	C57BL/6N-Ino80^{tm1a(EUCOMM)Hmgu}/Ics
Cell Lines	HEPD0509_6_D10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^{tm1a(EUCOMM)Hmgu} mutation (1 available); any Ino80 mutation (437 available)

Data Sources

IMPC Data for Ino80

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased exploration in new environment ( J:211773 )

IMPC - ICS

increased aggression ( J:211773 )

IMPC - ICS

decreased locomotor activity ( J:211773 )

IMPC - ICS

abnormal vocalization ( J:211773 )

IMPC - ICS

cardiovascular system

prolonged QRS complex duration ( J:211773 )

IMPC - ICS

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:211773 )

IMPC - ICS

reproductive system

abnormal seminal vesicle morphology ( J:211773 )

IMPC - ICS

Allelic Composition	Ino80^tm1.1Schg/Ino80⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Schg mutation (0 available); any Ino80 mutation (437 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:221224 )

• about 21% of mice exhibit defects in the hind limb extension reflex as early as 8 weeks of age

growth/size/body

decreased body size ( J:221224 )

• 12 week old mice with defects in extension reflex exhibit smaller body size

Allelic Composition	Ino80^tm1.1Schg/Ino80⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Schg mutation (0 available); any Ino80 mutation (437 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

decreased lymphoma incidence ( J:221224 )

• lower incidence of lymphomas compared to Trp53^tm1Tyj null mice

increased sarcoma incidence ( J:221224 )

• 10 of 20 mice develop poorly differentiated and highly invasive soft tissue sarcomas

• while double mutants exhibit an altered spectrum of tumors compared to single Trp53^tm1Tyj, tumor incidence and latency are similar to these mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

immune system

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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