Ino80^tm1.1Schg
Targeted Allele Detail

Summary

• Symbol: Ino80^tm1.1Schg
• Name: INO80 complex subunit; targeted mutation 1.1, Sandy Chang
• MGI ID: MGI:5698826
• Synonyms: mIno80^-
• Gene: Ino80 Location: Chr2:119203523-119308168 bp, - strand Genetic Position: Chr2, 59.97 cM, cytoband E5
• Alliance: Ino80^tm1.1Schg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:221224
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site and an FRT-flanked neomycin selection cassette was inserted into intron 2. A single loxP site was inserted into intron 4. Exons 3 and 4 were deleted via Cre-mediated recombination of loxP sites. No detectable wild-type transcript or encoded protein is present in MEFs derived from homozygous mutant mice. (J:221224)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ino80 Mutation: 440 strains or lines available

References

• Original: J:221224 Min JN, et al., The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability. Cell Res. 2013 Dec;23(12):1396-413
• All: 1 reference(s)