All Phenotypes Ino80<tm1.1Schg> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ino80^tm1.1Schg
targeted mutation 1.1, Sandy Chang
MGI:5698826

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ino80^tm1.1Schg/Ino80^tm1.1Schg	involves: C57BL/6J	MGI:5898010
ht2	Ino80^tm1.1Schg/Ino80⁺	involves: C57BL/6J	MGI:5898011
cx3	Ino80^tm1.1Schg/Ino80⁺ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6J	MGI:5898013
cx4	Ino80^tm1.1Schg/Ino80^tm1.1Schg Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6J	MGI:5898012

Allelic Composition	Ino80^tm1.1Schg/Ino80^tm1.1Schg
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Schg mutation (0 available); any Ino80 mutation (440 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

embryonic growth retardation ( J:221224 )

• all E7.5-E8.5 embryos exhibit severe growth retardation

mortality/aging

embryonic lethality, incomplete penetrance ( J:221224 )

• between E7.5-E10.5 the fraction of embryos was below the expected Mendelian ratio

• by E13.5-E14.5 the majority of embryos were resorbed

preweaning lethality, complete penetrance ( J:221224 )

• by P21 no embryos survived

embryo

abnormal embryo development ( J:221224 )

• all E7.5-E8.5 embryos exhibit intrauterine developmental abnormalities

embryonic growth retardation ( J:221224 )

• all E7.5-E8.5 embryos exhibit severe growth retardation

Allelic Composition	Ino80^tm1.1Schg/Ino80⁺
Genetic Background	involves: C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Schg mutation (0 available); any Ino80 mutation (440 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:221224 )

• about 21% of mice exhibit defects in the hind limb extension reflex as early as 8 weeks of age

growth/size/body

decreased body size ( J:221224 )

• 12 week old mice with defects in extension reflex exhibit smaller body size

Allelic Composition	Ino80^tm1.1Schg/Ino80⁺ Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ino80^tm1.1Schg mutation (0 available); any Ino80 mutation (440 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

decreased lymphoma incidence ( J:221224 )

• lower incidence of lymphomas compared to Trp53^tm1Tyj null mice

increased sarcoma incidence ( J:221224 )

• 10 of 20 mice develop poorly differentiated and highly invasive soft tissue sarcomas

• while double mutants exhibit an altered spectrum of tumors compared to single Trp53^tm1Tyj, tumor incidence and latency are similar to these mice

Allelic Composition	Ino80^tm1.1Schg/Ino80^tm1.1Schg Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, incomplete penetrance ( J:221224 )

• loss of Trp53 does not delay embryonic lethality

preweaning lethality, complete penetrance ( J:221224 )

• by P21 no embryos survived

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23