Phenotypes associated with this allele

• Allele Symbol: Ino80^tm1.1Schg
• Allele Name: targeted mutation 1.1, Sandy Chang
• Allele ID: MGI:5698826
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ino80^tm1.1Schg/Ino80^tm1.1Schg	involves: C57BL/6J	MGI:5898010
ht2	Ino80^tm1.1Schg/Ino80^+	involves: C57BL/6J	MGI:5898011
cx3	Ino80^tm1.1Schg/Ino80^+ Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6J	MGI:5898013
cx4	Ino80^tm1.1Schg/Ino80^tm1.1Schg Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129S2/SvPas * C57BL/6J	MGI:5898012

Genotype
MGI:5898010

hm1

• Allelic Composition: Ino80^tm1.1Schg/Ino80^tm1.1Schg
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

embryonic growth retardation ( J:221224 )

• all E7.5-E8.5 embryos exhibit severe growth retardation

mortality/aging

embryonic lethality, incomplete penetrance ( J:221224 )

• between E7.5-E10.5 the fraction of embryos was below the expected Mendelian ratio

• by E13.5-E14.5 the majority of embryos were resorbed

preweaning lethality, complete penetrance ( J:221224 )

• by P21 no embryos survived

embryo

abnormal embryo development ( J:221224 )

• all E7.5-E8.5 embryos exhibit intrauterine developmental abnormalities

embryonic growth retardation ( J:221224 )

• all E7.5-E8.5 embryos exhibit severe growth retardation

Genotype
MGI:5898011

ht2

• Allelic Composition: Ino80^tm1.1Schg/Ino80⁺
• Genetic Background: involves: C57BL/6J

behavior/neurological

limb grasping ( J:221224 )

• about 21% of mice exhibit defects in the hind limb extension reflex as early as 8 weeks of age

growth/size/body

decreased body size ( J:221224 )

• 12 week old mice with defects in extension reflex exhibit smaller body size

Genotype
MGI:5898013

cx3

• Allelic Composition: Ino80^tm1.1Schg/Ino80⁺; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

neoplasm

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

decreased lymphoma incidence ( J:221224 )

• lower incidence of lymphomas compared to Trp53^tm1Tyj null mice

increased sarcoma incidence ( J:221224 )

• 10 of 20 mice develop poorly differentiated and highly invasive soft tissue sarcomas

• while double mutants exhibit an altered spectrum of tumors compared to single Trp53^tm1Tyj, tumor incidence and latency are similar to these mice

hematopoietic system

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

immune system

increased T cell derived lymphoma incidence ( J:221224 )

• 7 of 20 mice develop thymic lymphomas

Genotype
MGI:5898012

cx4

• Allelic Composition: Ino80^tm1.1Schg/Ino80^tm1.1Schg; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

mortality/aging

embryonic lethality, incomplete penetrance ( J:221224 )

• loss of Trp53 does not delay embryonic lethality

preweaning lethality, complete penetrance ( J:221224 )

• by P21 no embryos survived