Phenotypes associated with this allele
neoplasm
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• following administration of inhaled adenovirus cre, mice develop fewer lung tumors than in Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca or Krastm4Tyj/Kras+ Pik3r2tm1Lca/Pik3r2tm1Lca Pik3r1tm1Lca/Pik3r1+ mice
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neoplasm
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• following administration of inhaled adenovirus cre
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respiratory system
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• following administration of inhaled adenovirus cre
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation
(1 available);
any
Pik3r1 mutation
(55 available)
Tg(Ckmm-cre)5Khn mutation
(4 available)
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normal phenotype
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• mutants are viable and fertile, with no gross abnormalities and normal muscle morphology
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cardiovascular system
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• most cardiomyocytes are reduced in size
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• heart size normalized to body weight or tibia length is about 20% smaller than in wild-type mice; however the structure of the heart is normal with no obvious signs of fibrosis or tissue damage
• the increase in heart size in response to exercise is decreased compared to wild-type mice
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muscle
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• most cardiomyocytes are reduced in size
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Lca mutation
(1 available);
any
Pik3r1 mutation
(55 available)
Tg(OPN1LW-cre)4Yzl mutation
(1 available)
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vision/eye
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• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
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• retinas show patchy regions devoid of cones by 6 months and cone photoreceptor loss is further exacerbated by 12 months of age
• the inferior meridian region of the retinas shows greater cone loss than the superior region at 6 months but by 12 months, similar loss of cones is seen in both regions
• however, the overall morphology and structural integrity of the retina are similar to wild-type mice at 1, 6, and 12 months of age
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• scotopic b-wave amplitudes are lower at 6 and 12 months of age compared with control floxed mice but are not different from control cre-only expressing mice
• photopic ERG b-wave amplitudes are decreased at 6 months, but not 1 month of age, and decrease progressively to 12 months
• however, scotopic ERG recordings of rod photoreceptors (scotopic a-wave) are normal at 1, 6, and 12 months of age
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nervous system
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• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
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• retinas show patchy regions devoid of cones by 6 months and cone photoreceptor loss is further exacerbated by 12 months of age
• the inferior meridian region of the retinas shows greater cone loss than the superior region at 6 months but by 12 months, similar loss of cones is seen in both regions
• however, the overall morphology and structural integrity of the retina are similar to wild-type mice at 1, 6, and 12 months of age
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• progressive disorganization of synaptic ultrastructure is seen in the terminals of surviving cones at 6 and 12 months of age but not at 1 month
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• cone terminals in the retina ribbon synaptic complexes are reduced, flat contacts are sometimes located adjacent to synaptic ribbons, and interactions with postsynaptic processes appear disorganized
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