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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pknox1Gt(OST71835)Lex
gene trap OST71835, Lexicon Genetics
MGI:3530910
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex B6.129S5-Pknox1Gt(OST71835)Lex MGI:4460937
hm2
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex involves: 129S5/SvEvBrd MGI:5469882
hm3
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex involves: 129S5/SvEvBrd * C57BL/6 MGI:3611267
hm4
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609796


Genotype
MGI:4460937
hm1
Allelic
Composition
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
Genetic
Background
B6.129S5-Pknox1Gt(OST71835)Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1Gt(OST71835)Lex mutation (2 available); any Pknox1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between E17.5 and P0

cardiovascular system
• at E10.5, mice exhibit a decreased vascular tree at the level of the head and intersomitic vessels compared with wild-type mice
• in culture, E7.5 to E7.75 allantois cells exhibit reduced angiogenesis with fewer capillaries and reduced vasculature complexity compared with wild-type cells
• in 13% of mice

vision/eye
• in 62% of mice at E14.5
• mice exhibit anomalies and duplications compared with wild-type mice
• in 40% of mice
• 14% of mice exhibit eyes that are still encased deep within the head unlike wild-type mice

hematopoietic system
• at E15.5, mice exhibit a decrease in total fetal liver cells, an increase in early progenitor subpopulations R2 and R3, and a decrease in the R4 subpopulation compared with wild-type mice
• at E16.5, mice exhibit an increased difference in progenitor cells compared with wild-type mice
• at E16.5
• generated from fetal liver cells

homeostasis/metabolism
• in 67% of mice at E15.5

growth/size/body
• at E15.5, mice exhibit general organ hypoplasia compared with wild-type mice
• in 75% of mice at E15.5

liver/biliary system
• 71% of mice exhibit smaller liver spots than in wild-type mice

pigmentation
• mice exhibit anomalies and duplications compared with wild-type mice

integument
• in 75% of mice at E15.5




Genotype
MGI:5469882
hm2
Allelic
Composition
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
Genetic
Background
involves: 129S5/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1Gt(OST71835)Lex mutation (2 available); any Pknox1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• fetal livers cells are less competent in transplantation assays than wild-type cells




Genotype
MGI:3611267
hm3
Allelic
Composition
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1Gt(OST71835)Lex mutation (2 available); any Pknox1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• variable penetrance of lethality is seen after E17.5 but before P0 with only 6% homozygous offspring from heterozygous crosses instead of the expected 25%

immune system
• the absolute number of double positive T cells in the thymus is similar to wild-type; however apoptosis of double positive T cells is increased
• thymic cellularity is reduced after 12 weeks of age by up to 30% and this is more evident in males
• in the thymus the number of double negative progenitors is increased
• the percentage of CD4+ or CD8+ cells is reduced by 40% in the spleen and blood and by 20-30% in the lymph nodes
• the absolute number of mature CD4+ and CD8+ cells in the lymph nodes is reduced by more than 50%
• in the thymus the number of single positive T cells is reduced 2- to 3-fold

growth/size/body
• homozygotes are smaller at birth but catch up to littermates by 2 to 3 months of age

hematopoietic system
• the absolute number of double positive T cells in the thymus is similar to wild-type; however apoptosis of double positive T cells is increased
• thymic cellularity is reduced after 12 weeks of age by up to 30% and this is more evident in males
• in the thymus the number of double negative progenitors is increased
• the percentage of CD4+ or CD8+ cells is reduced by 40% in the spleen and blood and by 20-30% in the lymph nodes
• the absolute number of mature CD4+ and CD8+ cells in the lymph nodes is reduced by more than 50%
• in the thymus the number of single positive T cells is reduced 2- to 3-fold

cellular
• the absolute number of double positive T cells in the thymus is similar to wild-type; however apoptosis of double positive T cells is increased

endocrine/exocrine glands
• thymic cellularity is reduced after 12 weeks of age by up to 30% and this is more evident in males




Genotype
MGI:3609796
hm4
Allelic
Composition
Pknox1Gt(OST71835)Lex/Pknox1Gt(OST71835)Lex
Genetic
Background
involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pknox1Gt(OST71835)Lex mutation (2 available); any Pknox1 mutation (79 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mean total tissue mass is reduced in male homozygotes

adipose tissue
• mean percent total body fat is reduced in male homozygotes





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/17/2023
MGI 6.22
The Jackson Laboratory