Analysis Tools
behavior/neurological
polyphagia
(
J:94820
)
|
• food intake was increased by 10% in 24 week old males
|
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• males had decreased spontaneous locomotor activity
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growth/size/body
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• by 10 weeks of age, males but not females showed a significant increase in body weight that became evident throughout adulthood and was even more pronounced by 52 weeks of age
|
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• males fed a high-fat diet showed a significant increase in body weight at an earlier age than controls
|
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• pale and enlarged liver in 52 week old males
|
homeostasis/metabolism
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• males fed a high-fat diet showed a significant increase in body weight at an earlier age than controls
|
hyperglycemia
(
J:94820
)
|
• normal glucose levels at 24 weeks of age, however by 52 weeks of age, males were hyperglycemic
|
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• slight increase in insulin levels at 24 weeks of age and became hyperinsulinemic at 52 weeks of age
|
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• higher leptin levels at 24 weeks of age and became significantly hyperleptinemic at 52 weeks of age
|
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• males had decreased resting oxygen consumption and decreased carbon dioxide production
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• higher total body lipid mass at 24 and 52 weeks of age than wild-type
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liver/biliary system
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• pale and enlarged liver in 52 week old males
|
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• 52 week old males exhibited fatty liver
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