All Phenotypes Hes3<tm1Kag> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hes3^tm1Kag
targeted mutation 1, Ryoichiro Kageyama
MGI:3521989

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hes3^tm1Kag/Hes3^tm1Kag	involves: C57BL/6 * CBA * ICR	MGI:3526241
cn2	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808127
cn3	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:3808125
cx4	Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:3526895
cx5	Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag	involves: C57BL/6 * CBA * ICR	MGI:3526242

Allelic Composition	Hes3^tm1Kag/Hes3^tm1Kag
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:71074 )

• mutants are fertile with no obvious defects

Allelic Composition	Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu Tg(Nes-cre/ERT2)5-1Imayo/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (21 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)
Tg(Nes-cre/ERT2)5-1Imayo mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:139170 )

N	• mice exhibit no change in Cajal-Retzius cell number

Allelic Composition	Emx1^tm1(cre)Ito/Emx1⁺ Hes1^tm1Kag/Hes1^tm1Kag Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx1^tm1(cre)Ito mutation (1 available); any Emx1 mutation (34 available)
Hes1^tm1Kag mutation (2 available); any Hes1 mutation (21 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

abnormal brain morphology ( J:139170 )

• mice exhibit mild abnormalities in the cortical hem and cortical neuroepithelium

increased Cajal-Retzius cell number ( J:139170 )

• at E11.5 and E12.5, the number of Cajal-Retzius cells in the marginal zone of the piriform cortex is increased compared to in wild-type mice

absent choroid plexus ( J:139170 )

embryo

abnormal embryonic neuroepithelium morphology ( J:139170 )

• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified

cellular

abnormal neuron differentiation ( J:139170 )

• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon

Allelic Composition	Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag Hes5^tm1Fgu/Hes5^tm1Fgu
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes1^tm1Fgu mutation (1 available); any Hes1 mutation (21 available)
Hes3^tm1Kag mutation (2 available); any Hes3 mutation (18 available)
Hes5^tm1Fgu mutation (1 available); any Hes5 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

premature neuronal precursor differentiation ( J:94391 )

• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5

• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated

cellular

premature neuronal precursor differentiation ( J:94391 )

• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5

• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated

Allelic Composition	Hes1^tm1Fgu/Hes1^tm1Fgu Hes3^tm1Kag/Hes3^tm1Kag
Genetic Background	involves: C57BL/6 * CBA * ICR

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:71074 )

• most homozygous double mutants survive to E10.5 but die by E15.5

growth/size/body

embryonic growth retardation ( J:71074 )

• at E10.5 embryos show signs of growth retardation

nervous system

premature neuronal precursor differentiation ( J:71074 )

• at E10.5 more neurons are generated prematurely however many neuronal precursors remain

abnormal neural tube morphology ( J:71074 )

• all double homozygotes had some type of neural tube defect

abnormal brain development ( J:71074 )

abnormal midbrain-hindbrain boundary morphology ( J:71074 )

• at E10.5 the isthmic organizer is prematurely lost as a result of premature differentiation of neuronal precursors

abnormal midbrain morphology ( J:71074 )

• the oculomotor and trochlear motor nuclei are absent at E10.5 and E12.5

abnormal oculomotor nucleus morphology ( J:71074 )

• the oculomotor nuclei are absent at E10.5 and E12.5

abnormal locus ceruleus morphology ( J:71074 )

• the locus ceruleus is absent at E10.5

exencephaly ( J:71074 )

• some embryos had exencephaly of the whole brain while in others the defect was confined to the midbrain-hindbrain region

abnormal dopaminergic neuron morphology ( J:71074 )

• dopaminergic neurons are absent at E11.5

absent oculomotor nerve ( J:71074 )

• at E12.5 the oculomoter nerve is absent

absent trochlear nerve ( J:71074 )

• at E12.5 the trochlear nerve is absent

embryo

embryonic growth retardation ( J:71074 )

• at E10.5 embryos show signs of growth retardation

abnormal neural tube morphology ( J:71074 )

• all double homozygotes had some type of neural tube defect

cellular

premature neuronal precursor differentiation ( J:71074 )

• at E10.5 more neurons are generated prematurely however many neuronal precursors remain

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