• dendritic trees of pyramidal cells in the CA1 region of the hippocampus are less complex than in wild-type mice
• the length of dendrites formed by granule cells in the dentate gyrus is increased (197+/-7 um compared to 164+/-7 um in wild-type mice)
• the complexity of apical dendrites in CA1 is reduced
• however, the complexity of granule cell dendrites in the dentate gyrus and the length of apical dendrites are normal
• in culture, dendrites of hippocampal neurons are 56% longer at day 3 and 88% longer at day 7 compared to wild-type neurons and the number of dendrites per cell is increased (1.8+/-0.2 compared to 1.2+/-0.1 for wild-type neurons) without affecting axon length, the number of axons per cell or the number of dendrites per cell