All Phenotypes Myf6<tm1(cre)Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myf6^tm1(cre)Mrc
targeted mutation 1, Mario R Capecchi
MGI:3487371

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3510829
cn2	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844657
cn3	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844658
cn4	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Myf6^tm1(cre)Mrc/Myf6⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3783879
cn5	Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}/Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710997
cn6	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3710996
cn7	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844659
cn8	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844656
cn9	Foxo1^tm1Mrc/Foxo1^tm1Mrc Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:3844661

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:93444 )

• homozygotes are normal and fertile with no rib fusions detected

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)
Pax3^tm1Mrc mutation (0 available); any Pax3 mutation (51 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 12 mice develop an rhabdomyosarcoma by day 202

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 12 mice develop an rhabdomyosarcoma by day 202

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 2 in 5 mice develop an rhabdomyosarcoma by day 75 to 91

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Gt(ROSA)26Sor^tm1(DTA)Mrc/Gt(ROSA)26Sor⁺ Myf6^tm1(cre)Mrc/Myf6⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:133338 )

• pups are immobile and die shortly after birth

muscle

abnormal myogenesis ( J:133338 )

• myogenesis appears normal at E12.5

• increasing apoptosis until all differentiating myofibers are either dead or dying at E18.5

abnormal skeletal muscle fiber morphology ( J:133338 )

• newborns lack differentiated myofibers

• basophilic clumps of cellular debris suggest skeletal muscle forms and then degenerates

Allelic Composition	Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc}/Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm3(SS18/EGFP)Mrc} mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:120967 )

• mice die by 6 months of age

neoplasm

neoplasm ( J:120967 )

N	• unlike in other Gt(ROSA)26Sor^tm3(SS18)Mrc homozygously activated mice, no tumors form

muscle

myopathy ( J:120967 )

• myopathy is characterized by abnormal wavy fiber and limited rhabdomyolysis

Allelic Composition	Gt(ROSA)26Sor^tm2(SS18)Mrc/Gt(ROSA)26Sor^tm2(SS18)Mrc Myf6^tm1(cre)Mrc/Myf6^tm1(cre)Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm2(SS18)Mrc mutation (0 available); any Gt(ROSA)26Sor mutation (1046 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:120967 )

• mice die by 6 months of age

neoplasm

neoplasm ( J:120967 )

N	• unlike in other Gt(ROSA)26Sor^tm2(SS18)Mrc homozygously activated mice, no tumors form

muscle

abnormal skeletal muscle morphology ( J:120967 )

• intrafiber vacuolation is present in some muscle fibers

• apoptosis of differentiated skeletal muscle fibers is increased

centrally nucleated skeletal muscle fibers ( J:120967 )

• central nuclei are present in some muscle fibers

myopathy ( J:120967 )

• myopathy is characterized by abnormal wavy fiber and limited rhabdomyolysis

Allelic Composition	Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2a^tm4Rdp mutation (0 available); any Cdkn2a mutation (59 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)
Pax3^tm1Mrc mutation (0 available); any Pax3 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 4 in 14 mice develop an rhabdomyosarcoma by day 56 to 89

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383

muscle

increased rhabdomyosarcoma incidence ( J:93444 )

• 1 in 228 mice develop an rhabdomyosarcoma that arises from the pectoralis major muscle by day 383

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alveolar rhabdomyosarcoma		DOID:4051	OMIM:268220	J:93444

Allelic Composition	Foxo1^tm1Mrc/Foxo1^tm1Mrc Myf6^tm1(cre)Mrc/Myf6⁺ Pax3^tm1Mrc/Pax3^tm1Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Mrc mutation (0 available); any Foxo1 mutation (34 available)
Myf6^tm1(cre)Mrc mutation (0 available); any Myf6 mutation (18 available)
Pax3^tm1Mrc mutation (0 available); any Pax3 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:93444 )

N	• mice do not exhibit accelerated tumorigenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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