Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10atm2(cre)Jwo mutation
(3 available);
any
Scn10a mutation
(102 available)
Scn9atm1Jwo mutation
(0 available);
any
Scn9a mutation
(120 available)
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behavior/neurological
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• inflammation does not result in thermal or mechanical hyperalgesia in mutants unlike in wild-type mice
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• homozygotes are significantly less sensitive to noxious mechanical stimulation compared to wild-type mice
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• mutants are about 20% less sensitive to noxious thermal stimulation compared to wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Cpri mutation
(0 available);
any
Braf mutation
(58 available)
Scn10atm2(cre)Jwo mutation
(3 available);
any
Scn10a mutation
(102 available)
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behavior/neurological
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N |
• behavioral responses to pain and motor functions are similar to controls prior to the onset of scratching
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• at 4 to 6 weeks of age, show enhanced scratching responses to pruritogens injected into the nape
• both histaminergic and nonhistaminergic itch are significantly enhanced
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• age-dependent excessive scratching from 6 to 14 weeks of age, with about 50% of mice showing excessive scratching at 6 weeks of age
• at 4 to 6 weeks of age, show enhanced scratching responses to pruritogens injected into the nape
• both histaminergic and nonhistaminergic itch are significantly enhanced
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integument
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• develop after the onset of excessive scratching
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nervous system
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• increase in the density of primary afferent fibers innervating the cervical and lumbar back hairy skin regions
• in the spinal cord CGRP+ fibers expand into lamina II inner layer and nonpeptidergic
• IB4+ fibers invade into laminae I and II outer layer domains
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• increase in the number of pERK+ cells in dorsal root ganglion neurons at the cervical, thoracic and lumbar segmental levels
• the number of GRP+ neurons is nearly doubled
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• the percentage of single spike cells is decreased while the percentage of delayed firing cells is almost
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• increase in the percentage of dorsal root ganglion cells responding to chloroquine and histamine
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behavior/neurological
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N |
• spontaneous scratching, seen in mutant mice wild-type for Grpr, is markedly diminished
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behavior/neurological
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N |
• spontaneous scratching, seen in mutant mice wild-type for Grp, is markedly diminished
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn10atm2(cre)Jwo mutation
(3 available);
any
Scn10a mutation
(102 available)
Slc12a6tm2.1Dlp mutation
(0 available);
any
Slc12a6 mutation
(120 available)
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behavior/neurological
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N |
• mice display no locomotor deficit in the accelerated rotarod and open field tests and show a normal response latency to heat-evoked nociceptive stimuli in a hot plate assay
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hcn2tm1.1Lex mutation
(0 available);
any
Hcn2 mutation
(29 available)
Scn10atm2(cre)Jwo mutation
(3 available);
any
Scn10a mutation
(102 available)
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behavior/neurological
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• in a neuropathic pain model, mice do not exhibit heat or mechanical hyperalgesia or cold allodynia unlike similarly treated wild-type mice
• however, mechanical hyperalgesia is normal
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• formalin-treated mice exhibit attenuated late phase pain response compared with similarly treated wild-type mice
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• thermal hyperalgesia after carrageenan injection to induce long-lasting inflammation is completely abolished
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• PGE2-induced thermal hyperalgesia is abolished
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nervous system
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• about a 50% decrease in tetrodotoxin-resistant current density in whole-cell voltage clamp assays of dorsal root ganglia neurons, but no difference in tetrodotoxin-sensitive current density
• decrease in total evoked neuron activity in wide dynamic range (WDR) spinal neurons following noxious pinch stimulation but not after noxious cold or brush stimulation
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behavior/neurological
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• increased pain threshold following noxious mechanical stimuli applied to the tail but not to the paw
• no significant difference in response to noxious radiant or in hotplate latency
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• reduction in mechanical allodynia following L5 spinal nerve injury
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behavior/neurological
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N |
• mice exhibit normal responses to acute noxious heat, low-threshold and noxious mechanical stimuli and chemical/early inflammatory pain in the formalin test
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• following CFA treatment, mice exhibit increased intensity and duration of mechanical allodynia compared with control mice
• however, heat hyperalgesia is normal
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homeostasis/metabolism
behavior/neurological
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N |
• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception
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• under inflammatory pain, mice exhibit decreased mu opiate-induced analgesia compared with control mice
• under inflammatory pain, mice exhibit decreased analgesia to the peripheral opiate loperamide compared with control mice
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homeostasis/metabolism
integument
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N |
• mice exhibit normal nociception thresholds, morphine-induced antinociception and tolerance to antinociception
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behavior/neurological
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N |
• mice exhibit normal recovery from carrageenan-induced inflammatory hyperalgesia
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behavior/neurological
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N |
• mice show a non-significant tendency towards increased spontaneous scratching behavior as well as a similar tendency to decreased thermal pain response
• in response to an exogenous pruritogen mice show elevated scratching although response is somewhat delayed
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behavior/neurological
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N |
• mice exhibit normal neuropathic pain behavior
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Analysis Tools