Oprd1^tm1.1Cgrf
Targeted Allele Detail

Summary

• Symbol: Oprd1^tm1.1Cgrf
• Name: opioid receptor, delta 1; targeted mutation 1.1, Claire Gaveriaux-Ruff
• MGI ID: MGI:5562342
• Synonyms: Oprd1^fl
• Gene: Oprd1 Location: Chr4:131838037-131871797 bp, - strand Genetic Position: Chr4, 64.78 cM, cytoband D1-D3
• Alliance: Oprd1^tm1.1Cgrf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208176
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed hygromycin resistance gene was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the selection cassette and left exon 2 floxed. (J:208176)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprd1 Mutation: 29 strains or lines available

References

• Original: J:208176 Gaveriaux-Ruff C, et al., Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia. Pain. 2011 Jun;152(6):1238-48
• All: 9 reference(s)