All Phenotypes Epor<tm1.1(EGFP/icre)Uk> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Epor^{tm1.1(EGFP/icre)Uk}
targeted mutation 1.1, Ursula Klingmuller
MGI:3052727

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epor^{tm1.1(EGFP/icre)Uk}/Epor^{tm1.1(EGFP/icre)Uk}	involves: BALB/cJ	MGI:3718192
cn2	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a⁺ Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: 129 * BALB/cJ	MGI:5515311
cn3	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: 129 * BALB/cJ	MGI:5515313
cn4	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Tg(HBB)8.1Gvs/0	involves: 129 * BALB/cJ * FVB/N	MGI:5496871
cn5	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Klf1^tm1Nimr/Klf1⁺ Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Tg(HBB)8.1Gvs/0	involves: 129P2/OlaHsd * BALB/cJ * FVB/N	MGI:5496872
cn6	Eed^tm1Sho/Eed^tm1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ	MGI:4410547
cn7	Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Rasa3^tm1.1Llp/Rasa3^tm1.1Llp	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J	MGI:6509624
cn8	Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Rasa3^tm1.1Llp/Rasa3^tm1.3Llp	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J	MGI:6510263
cn9	Slc29a1^tm2Msg/Slc29a1^tm2Msg Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: 129X1/SvJ * BALB/cJ	MGI:6151074
cn10	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: BALB/cJ	MGI:5515310
cn11	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺	involves: BALB/cJ * C57BL/6	MGI:6712738

Allelic Composition	Epor^{tm1.1(EGFP/icre)Uk}/Epor^{tm1.1(EGFP/icre)Uk}
Genetic Background	involves: BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:92235 )

• mice die at E12.5

Allelic Composition	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Kdm1a^tm1.1Sho/Kdm1a⁺ Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: 129 * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11a^tm1Pwt mutation (0 available); any Bcl11a mutation (42 available)
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:196140 )

• mild

decreased erythrocyte cell number ( J:196140 )

decreased hemoglobin content ( J:196140 )

Allelic Composition	Kdm1a^tm1.1Sho/Kdm1a^tm1.1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: 129 * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Kdm1a^tm1.1Sho mutation (1 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:201572 )

• embryos are smaller than control at E13.5

growth/size/body

decreased embryo size ( J:201572 )

• embryos are smaller than control at E13.5

hematopoietic system

abnormal erythropoiesis ( J:201572 )

abnormal proerythroblast morphology ( J:201572 )

• 300% increase in CD71^hi Ter119^low proerythroblasts found in fetal liver cells

decreased fetal derived definitive erythrocyte cell number ( J:201572 )

• 20-fold decrease in number of erythrocytes found in fetal (E13.5) liver cells

reticulocytopenia ( J:201572 )

• 20-fold decrease in number of reticulocytes found in fetal (E13.5) liver cells

liver/biliary system

abnormal liver morphology ( J:201572 )

• E13.5 livers exhibit a disturbed architecture with multiple pyknotic cells displaying karyorrhexis

pale liver ( J:201572 )

• fetal liver (E13.5) is pale

Allelic Composition	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Tg(HBB)8.1Gvs/0
Genetic Background	involves: 129 * BALB/cJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11a^tm1Mbu mutation (0 available); any Bcl11a mutation (42 available)
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Tg(HBB)8.1Gvs mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:196405 )

N	• mice are produced in expected Mendelian ratios

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased Ter119+/CD71+ cells in the blood

• increased Ter119+/DRAQ5+ cells in the blood

anemia ( J:196405 )

• mild

decreased erythrocyte cell number ( J:196405 )

• small

decreased hematocrit ( J:196405 )

• small

decreased hemoglobin content ( J:196405 )

• small

reticulocytosis ( J:196405 )

homeostasis/metabolism

increased circulating erythropoietin level ( J:196405 )

• indicating anemic stress

Allelic Composition	Bcl11a^tm1Mbu/Bcl11a^tm1Mbu Klf1^tm1Nimr/Klf1⁺ Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Tg(HBB)8.1Gvs/0
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythropoiesis ( J:196405 )

• increased Ter119+/CD71+ cells in the blood

polychromatophilia ( J:196405 )

Allelic Composition	Eed^tm1Sho/Eed^tm1Sho Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^tm1(EYFP)Cos
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eed^tm1Sho mutation (1 available); any Eed mutation (116 available)
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (11 available); any Gt(ROSA)26Sor mutation (942 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal erythropoiesis ( J:154730 )

• increase in the percentage of cells in the R2 stage (lin-,CD71+,Ter119-) and reduction in the percentage of cells in the R3 stage (lin-,CD71+,Ter119+)

Allelic Composition	Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Rasa3^tm1.1Llp/Rasa3^tm1.1Llp
Genetic Background	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Rasa3^tm1.1Llp mutation (0 available); any Rasa3 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:301035 )

• although there is efficient deletion of exon 3 in red cell precursors, mice are normal at birth and at 6-8 weeks of age with normal spleen weights, normal blood morphology, and normal blood counts except for a clinically insignificant decrease in platelet number and slight increase in circulating reticulocytes

Allelic Composition	Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺ Rasa3^tm1.1Llp/Rasa3^tm1.3Llp
Genetic Background	involves: 129S1/SvImJ * BALB/cJ * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:301035 )

Allelic Composition	Slc29a1^tm2Msg/Slc29a1^tm2Msg Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: 129X1/SvJ * BALB/cJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Slc29a1^tm2Msg mutation (0 available); any Slc29a1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal response to injury ( J:244602 )

• under acute hypoxic conditions, mice exhibit a faster increase in serum adenosine levels than in wild-type mice

decreased susceptibility to injury ( J:244602 )

• under acute hypoxic conditions, mice exhibit reduced tissue hypoxia in the heart, kidney and lung with reduced total cell numbers, albumin and IL6 concentration bronchoalveolar lavage fluid, pulmonary myeloperoxidase activity, and perivascular edema compared with wild-type mice

immune system

decreased interleukin-6 secretion ( J:244602 )

• in the lungs of mice exposed to hypoxic conditions

Allelic Composition	Bcl11a^tm1Pwt/Bcl11a^tm1Pwt Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: BALB/cJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:196140 )

N	• mice exhibit normal red blood cell numbers, white blood cell numbers and hemoglobin content

Allelic Composition	Il22ra1^tm1.1Koll/Il22ra1^tm1.1Koll Epor^{tm1.1(EGFP/icre)Uk}/Epor⁺
Genetic Background	involves: BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epor^{tm1.1(EGFP/icre)Uk} mutation (2 available); any Epor mutation (25 available)
Il22ra1^tm1.1Koll mutation (1 available); any Il22ra1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased erythroid progenitor cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in RIII and RIV erythroid precursors in the bone marrow compared to controls

increased erythrocyte cell number ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in peripheral blood red blood cell numbers compared to controls

increased hematocrit ( J:305794 )

• mice treated with phenylhydrazine to induce stress erythropoiesis show an increase in hematocrit compared to controls

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:305794 )

• mice show alleviation of stress-induced anemia, showing increased peripheral blood cell counts, increased hematocrit, and increase in erythroid precursors in the bone marrow following phenylhydrazine-induced stress erythropoiesis

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