About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nlrc4tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:3046934
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nlrc4tm1Vmd/Nlrc4tm1Vmd C57BL/6N-Nlrc4tm1Vmd MGI:3047280
hm2
Nlrc4tm1Vmd/Nlrc4tm1Vmd involves: C57BL/6N MGI:3625286
cn3
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce/Gt(ROSA)26Sor+
Lyz2tm1(cre)Ifo/Lyz2+
Nlrc4tm1Vmd/Nlrc4tm1Vmd
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NCrl MGI:6196855
cx4
Nlrc4tm1Vmd/Nlrc4tm1Vmd
Nlrp3tm1Vmd/Nlrp3tm1Vmd
C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd MGI:5428938


Genotype
MGI:3047280
hm1
Allelic
Composition
Nlrc4tm1Vmd/Nlrc4tm1Vmd
Genetic
Background
C57BL/6N-Nlrc4tm1Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation (1 available); any Nlrc4 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• caspase dependent cell death resulting from infection with Salmonella typhimurium reduced to minor levels

immune system
• negligible amounts of Il-1beta produced when infected with Salmonella typhimurium




Genotype
MGI:3625286
hm2
Allelic
Composition
Nlrc4tm1Vmd/Nlrc4tm1Vmd
Genetic
Background
involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation (1 available); any Nlrc4 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages




Genotype
MGI:6196855
cn3
Allelic
Composition
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce/Gt(ROSA)26Sor+
Lyz2tm1(cre)Ifo/Lyz2+
Nlrc4tm1Vmd/Nlrc4tm1Vmd
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce mutation (0 available); any Gt(ROSA)26Sor mutation (935 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
Nlrc4tm1Vmd mutation (1 available); any Nlrc4 mutation (67 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• neutrophilic inflammation is not apparent

skeleton
N
• mice exhibit normal joints




Genotype
MGI:5428938
cx4
Allelic
Composition
Nlrc4tm1Vmd/Nlrc4tm1Vmd
Nlrp3tm1Vmd/Nlrp3tm1Vmd
Genetic
Background
C57BL/6-Nlrp3tm1Vmd Nlrc4tm1Vmd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation (1 available); any Nlrc4 mutation (67 available)
Nlrp3tm1Vmd mutation (0 available); any Nlrp3 mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory