Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation
(1 available);
any
Nlrc4 mutation
(67 available)
|
|
|
cellular
|
• caspase dependent cell death resulting from infection with Salmonella typhimurium reduced to minor levels
|
immune system
|
• negligible amounts of Il-1beta produced when infected with Salmonella typhimurium
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation
(1 available);
any
Nlrc4 mutation
(67 available)
|
|
|
immune system
|
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
|
|
• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(OVAL/fla,GFP)Vnce mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(935 available)
Lyz2tm1(cre)Ifo mutation
(14 available);
any
Lyz2 mutation
(41 available)
Nlrc4tm1Vmd mutation
(1 available);
any
Nlrc4 mutation
(67 available)
|
|
|
immune system
N |
• neutrophilic inflammation is not apparent
|
skeleton
N |
• mice exhibit normal joints
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrc4tm1Vmd mutation
(1 available);
any
Nlrc4 mutation
(67 available)
Nlrp3tm1Vmd mutation
(0 available);
any
Nlrp3 mutation
(61 available)
|
|
|
immune system
|
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium
|