Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nlrc4tm1Vmd targeted mutation 1, Vishva M Dixit MGI:3046934 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• caspase dependent cell death resulting from infection with Salmonella typhimurium reduced to minor levels
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• negligible amounts of Il-1beta produced when infected with Salmonella typhimurium
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
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• macrophages from null mice exhibit almost undetectable Il-1beta release and no activation of caspase-1 in culture when infected with Salmonella, compared to wild-type or Cias- and Asc-deficient macrophages
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• neutrophilic inflammation is not apparent
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| N |
• mice exhibit normal joints
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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