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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(CMV-cre)Brd
targeted mutation 1, Allan Bradley
MGI:3046308
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/? 		involves: 129S7/SvEvBrd * C57BL/6J MGI:4889208
cn2
 		ApcMin/Apc+
Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/? 		involves: 129S7/SvEvBrd * C57BL/6J MGI:4889209
cn3
 		Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr 		involves: 129S/SvEv * 129S/SvEvBrd MGI:3689632
cn4
 		Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr 		involves: 129S/SvEv * 129S/SvEvBrd MGI:3689697


Genotype
MGI:4889208
cn1
Allelic
Composition		 Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gpa33tm1(GNAS)Wtsi mutation (0 available); any Gpa33 mutation (137 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
digestive/alimentary phenotype ( J:168378 )
N
• mice do not develop intestinal polyps




Genotype
MGI:4889209
cn2
Allelic
Composition		 ApcMin/Apc+
Gpa33tm1(GNAS)Wtsi/Gpa33+
Hprt1tm1(CMV-cre)Brd/?
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Gpa33tm1(GNAS)Wtsi mutation (0 available); any Gpa33 mutation (137 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:168378 )
• compared with ApcMin heterozygotes

digestive/alimentary system
increased intestinal adenoma incidence ( J:168378 )
• compared with ApcMin heterozygotes




Genotype
MGI:3689632
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sor+
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr
Genetic
Background		 involves: 129S/SvEv * 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (157 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:114455 )
• some mice (5/208) survive to birth while all Nf1-null homozygotes expressing either Gt(ROSA)26Sortm1Fia or Hprt1tm1(CMV-cre)Brd die prior to birth

nervous system
abnormal somatic sensory system morphology ( J:114455 )
• peripheral ganglia are massively enlarged in newborns
abnormal dorsal root ganglion morphology ( J:114455 )
• enormous paraspinal masses arise from the dorsal root ganglia

endocrine/exocrine glands
adrenal medulla hyperplasia ( J:114455 )
• medulla is overgrown compared with wild-type, with cortical effacement and tumor-like medullary protrusion

homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:114455 )
• elevate Ras levels return to wild-type levels by E12.5 with expression of Gt(ROSA)26Sortm1Fia




Genotype
MGI:3689697
cn4
Allelic
Composition		 Gt(ROSA)26Sortm1Fia/Gt(ROSA)26Sortm1Fia
Hprt1tm1(CMV-cre)Brd/Hprt1+
Nf1tm1Fcr/Nf1tm1Fcr
Genetic
Background		 involves: 129S/SvEv * 129S/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Fia mutation (0 available); any Gt(ROSA)26Sor mutation (944 available)
Hprt1tm1(CMV-cre)Brd mutation (0 available); any Hprt1 mutation (1274 available)
Nf1tm1Fcr mutation (3 available); any Nf1 mutation (157 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal somatic sensory system morphology ( J:114455 )
• peripheral ganglia are massively enlarged in newborns




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory