All Phenotypes Tg(EmuSR-tTa)83Bop MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(EmuSR-tTa)83Bop
transgene insertion 83, J Michael Bishop
MGI:3040386

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Trp53bp2^tm1Cdlo/Trp53bp2⁺ Tg(EmuSR-tTa)83Bop/0 Tg(tetO-MYC)36aBop/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3839868
cx2	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(EmuSR-tTa)83Bop/0 Tg(tetO-Nfatct1*)1Grc/0	involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N	MGI:3820654
cx3	Tg(EmuSR-tTa)83Bop/0 Tg(IghMyc)22Bri/0 Tg(tetO-RNAi:Trp53)ASlowe/0	involves: C57BL * C57BL/6 * FVB/N * SJL	MGI:5521543
cx4	Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop Tg(tetO-NPM1/ALK,-luc)2Gde/0	involves: FVB/N	MGI:5766492
cx5	Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop Tg(tetO-TPM3/ALK,-luc)2Gde/0	involves: FVB/N	MGI:5766494

Allelic Composition	Trp53bp2^tm1Cdlo/Trp53bp2⁺ Tg(EmuSR-tTa)83Bop/0 Tg(tetO-MYC)36aBop/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-MYC)36aBop mutation (1 available)
Trp53bp2^tm1Cdlo mutation (0 available); any Trp53bp2 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

hematopoietic system

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

immune system

increased T cell derived lymphoma incidence ( J:146764 )

• incidence of T cell lymphomas is similar to that in transgenic mice wild-type for Trp53bp2

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tg(EmuSR-tTa)83Bop/0 Tg(tetO-Nfatct1*)1Grc/0
Genetic Background	involves: 129S/SvEv * C57BL/6J * CBA/J * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (115 available)
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-Nfatct1*)1Grc mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal double-positive T cell morphology ( J:141917 )

• 4 to 30% DP thymocytes appear allowing some DN cells to progress to the DP state, which is fewer than in wild-type mice but more than in Rag2 null mice

immune system

abnormal double-positive T cell morphology ( J:141917 )

• 4 to 30% DP thymocytes appear allowing some DN cells to progress to the DP state, which is fewer than in wild-type mice but more than in Rag2 null mice

Allelic Composition	Tg(EmuSR-tTa)83Bop/0 Tg(IghMyc)22Bri/0 Tg(tetO-RNAi:Trp53)ASlowe/0
Genetic Background	involves: C57BL * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(IghMyc)22Bri mutation (2 available)
Tg(tetO-RNAi:Trp53)ASlowe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased tumor-free survival time ( J:123006 )

• mutants become moribund without a large peripheral tumor burden, with a median survival of 82 days

neoplasm

increased lymphoma incidence ( J:123006 )

• mutants develop lymphoma, with latency of tumorigenesis reduced compared to single Tg(IghMyc)22Bri/0 mice

• lymphoma-bearing mice treated with doxycycline at the onset of paralysis regain full movement within 2 days of doxycycline treatment, show tumor involution, and live for a further 24-64 days before tumors relapse

growth/size/body

enlarged spleen ( J:123006 )

• spleen is enlarged and taken over by B220+ IgM- (pre-B) tumor cells, with lymphoma dissemination into the lymph nodes and liver

hematopoietic system

enlarged spleen ( J:123006 )

• spleen is enlarged and taken over by B220+ IgM- (pre-B) tumor cells, with lymphoma dissemination into the lymph nodes and liver

immune system

enlarged spleen ( J:123006 )

• spleen is enlarged and taken over by B220+ IgM- (pre-B) tumor cells, with lymphoma dissemination into the lymph nodes and liver

behavior/neurological

hindlimb paralysis ( J:123006 )

• partial hind leg paralysis is seen in some mutants, most likely attributed to lymphoma

Allelic Composition	Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop Tg(tetO-NPM1/ALK,-luc)2Gde/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-NPM1/ALK,-luc)2Gde mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:160236 )

• mice die within a mean latency of 4 weeks when dox is removed at the newborn stage

embryonic lethality, complete penetrance ( J:160236 )

• embryonic lethality is seen in the absence of doxycycline (dox)

immune system

enlarged spleen ( J:160236 )

• splenomegaly in mice when dox is removed in newborns

enlarged lymph nodes ( J:160236 )

• generalized lymphadenopathy in mice when dox is removed in newborns

growth/size/body

postnatal growth retardation ( J:160236 )

• mice are growth retarded when dox is removed in newborns

enlarged spleen ( J:160236 )

• splenomegaly in mice when dox is removed in newborns

hematopoietic system

enlarged spleen ( J:160236 )

• splenomegaly in mice when dox is removed in newborns

integument

abnormal skin morphology ( J:160236 )

• induction of transgene expression by removal of dox in newborns results in the development of a skin disease affecting the snout and paws, first detectable at 3 weeks of age

abnormal dermal layer morphology ( J:160236 )

• lymphomatous infiltration is sometimes seen in the dermis below the keratoacanthoma-like lesions

epidermal hyperplasia ( J:160236 )

• mice exhibit skin nodules of a hyperplasia of the epidermis when dox is removed at the newborn stage, suggesting a keratoacanathoma-like lesion

• mice that are moribund with tumors and treated with dox for 12 days to suppress transgene expression exhibit a clearing of skin lesions and regrowth of hair within 3 weeks

• treatment of mice with an ALK phosphorylation inhibitor PF-2341066 results in a progressive clearing of skin lesions

neoplasm

increased leukemia incidence ( J:160236 )

• mice develop aggressive lymphoma/leukemia when dox is removed in newborns

• lymphoma/leukemia are derived from B cells

increased B cell derived lymphoma incidence ( J:160236 )

• mice develop aggressive lymphoma/leukemia when dox is removed in newborns

• lymphoma/leukemia are derived from B cells

• transplantation of mutant bone marrow into recipient mice results in the development of B-cell lymphoma without skin lesions

• mice that are moribund with tumors and treated with dox for 12 days exhibit tumor regression

• treatment of mice with an ALK phosphorylation inhibitor PF-2341066 results in tumor regression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-Hodgkin lymphoma		DOID:0060060	OMIM:605027	J:160236

Allelic Composition	Tg(EmuSR-tTa)83Bop/Tg(EmuSR-tTa)83Bop Tg(tetO-TPM3/ALK,-luc)2Gde/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(EmuSR-tTa)83Bop mutation (1 available)
Tg(tetO-TPM3/ALK,-luc)2Gde mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:160236 )

• mice die within a mean latency of 4 weeks when dox is removed at the newborn stage

embryonic lethality, complete penetrance ( J:160236 )

• embryonic lethality is seen in the absence of doxycycline (dox)

hematopoietic system

enlarged spleen ( J:160236 )

• splenomegaly in mice when dox is removed in newborns

integument

abnormal skin morphology ( J:160236 )

• induction of transgene expression by removal of dox in newborns results in the development of a skin disease affecting the snout and paws, first detectable at 3 weeks of age

abnormal dermal layer morphology ( J:160236 )

• lymphomatous infiltration is sometimes seen in the dermis below the keratoacanthoma-like lesions

epidermal hyperplasia ( J:160236 )

• mice exhibit skin nodules of a hyperplasia of the epidermis when dox is removed at the newborn stage, suggesting a keratoacanathoma-like lesion

• mice that are moribund with tumors and treated with dox for 12 days to suppress transgene expression exhibit a clearing of skin lesions and regrowth of hair within 3 weeks

immune system

enlarged spleen ( J:160236 )

• splenomegaly in mice when dox is removed in newborns

enlarged lymph nodes ( J:160236 )

• generalized lymphadenopathy in mice when dox is removed in newborns

neoplasm

increased leukemia incidence ( J:160236 )

• mice develop aggressive lymphoma/leukemia when dox is removed in newborns

• lymphoma/leukemia are derived from B cells

increased B cell derived lymphoma incidence ( J:160236 )

• mice develop aggressive lymphoma/leukemia when dox is removed in newborns

• lymphoma/leukemia are derived from B cells

• transplantation of mutant bone marrow into recipient mice results in the development of B-cell lymphoma without skin lesions

• mice that are moribund with tumors and treated with dox for 12 days exhibit tumor regression

growth/size/body

enlarged spleen ( J:160236 )

• splenomegaly in mice when dox is removed in newborns

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-Hodgkin lymphoma		DOID:0060060	OMIM:605027	J:160236

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