Analysis Tools
normal phenotype
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• mice were viable and born at the expected Mendelian frequency
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Allele Symbol Allele Name Allele ID |
Mcl1tm3Sjk targeted mutation 3, Stanley J Korsmeyer MGI:2684151 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice were viable and born at the expected Mendelian frequency
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased apoptosis at pro-B cell stage
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• arrested at pro-B cell stage
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• decrease in peripheral B cells
• 88% reduction of splenic B cells relative to controls
• near absence of lymph node B cells
• detected peripheral B cells did not undergo cre-mediated recombination
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• increased apoptosis at pro-B cell stage
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• arrested at pro-B cell stage
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• decrease in peripheral B cells
• 88% reduction of splenic B cells relative to controls
• near absence of lymph node B cells
• detected peripheral B cells did not undergo cre-mediated recombination
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• increased apoptosis at pro-B cell stage
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• eosinophil numbers in blood, spleen, and bone marrow are similar to controls, while neutrophil numbers in blood, bone marrow and peritoneal cavity are also similar to controls; a modest increase in neutrophils is observed in the spleen
• no signfiicant changes in T cell or B cell number are detected; absolute numbers of lymphocytes or myeloid cells in the blood are not significantly changed
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• mice exhibit a mild macrocytic anemia
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• significantly fewer basphils are observed in the spleen, bone marrow, and blood of 3-10 month-old mice compared with controls
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• mice show approximately a 31% reduction in erythrocytes in blood
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• a 24% reduction relative to controls is observed
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• 6 week to 10 month-old mice show significant reductions in mast cell numbers in almost all tissues and organs examined, except in the spleen
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• significantly fewer basphils are observed in the spleen, bone marrow, and blood of 3-10 month-old mice compared with controls
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• 6 week to 10 month-old mice show significant reductions in mast cell numbers in almost all tissues and organs examined, except in the spleen
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• IgE-dependent chronic allergic inflammation (CAI) is reduced; leukocyte infiltration into the dermis is almost absent and basophils are not detected 3 days after IgE challenge
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• in IgE-treated mice, IgE-dependent passive cutaneous anaphylaxis (PCA) is reduced compared to controls; tissue swelling is reduced relative to treated controls at 30 minutes after antigen challenge
• mast cell numbers in dermis of ear pinnae 6 hours after treatment with IgE are low and no detectable increase in dermal leukocytes is observed
• in IgE-dependent passive systemic anaphylaxis (PSA), IgE-sensitized mutants are essentially un reactive to challenge with IgE injection, whereas controls exhibit hypothermia and sometimes death in response to identical challenge
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• peripheral B cells are not maintained
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• peripheral T cells are not maintained
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• peripheral B cells are not maintained
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• peripheral T cells are not maintained
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased apoptosis at double negative T cell stage
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• block at the double-negative stage between DN2 and DN3
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• decreased number of peripheral T cells
• detected peripheral T cells did not undergo cre-mediated recombination
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• reduction of the total number of thymocytes
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• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets
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• increased apoptosis at double negative T cell stage
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• block at the double-negative stage between DN2 and DN3
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• decreased number of peripheral T cells
• detected peripheral T cells did not undergo cre-mediated recombination
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• reduction of the total number of thymocytes
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• reduction of double-negative cells in DN3 and DN4 subsets, but not in DN1 or DN2 subsets
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• increased apoptosis at double negative T cell stage
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• reduction of the total number of thymocytes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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