Analysis Tools
normal phenotype
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• homozygotes born at expected ratio
• normal size
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Allele Symbol Allele Name Allele ID |
Pdpk1tm1.1Mlw targeted mutation 1.1, Margaret A Lawlor MGI:2677461 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• homozygotes born at expected ratio
• normal size
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice succumb to disease at 12-16 weeks of age
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• marker analysis indicates impaired keratinocyte differentiation
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• mice develop mild skin dermatitis
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• mice develop mild skin dermatitis
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• marker analysis indicates impaired keratinocyte differentiation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice develop a wasting syndrome and succumb to disease by 11 weeks of age
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• mice develop an enlarged spleen
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• loss of hypodermal fat
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• marker analysis indicates impaired keratinocyte differentiation
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• mice with advanced disease show loss of skin barrier integrity at 7-8 weeks of age
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• mice develop severe, systemic dermatitis starting at 5 weeks of age
• inflammation is not seen in the lung, liver, kidney or gut
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• dermatitis is accompanied by hair loss
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• loss of hair follicles
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• mild epidermal hyperplasia and microabsceess are seen at 3 weeks of age but not at 10 days of age
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• skin contains epidermal scales
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• skin of mice with advanced disease contains lesions with epidermal damage, resulting in loss of skin barrier integrity
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• dermatitis is accompanied by skin thickening
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• increase in dermal fibrosis
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• mice develop an enlarged spleen
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• decrease in the frequency of Foxp3+ CD25+ Tregs with a corresponding increase in Foxp3-CD25+ effector T cells
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• CD4 T cells exhibit an activated phenotype
• mice develop systemic T helper type 2 immunity
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• mice develop peripheral lymphadenopathy
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• mice develop severe, systemic dermatitis starting at 5 weeks of age
• inflammation is not seen in the lung, liver, kidney or gut
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• mice with advanced disease show loss of skin barrier integrity at 7-8 weeks of age
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• mice develop an enlarged spleen
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• decrease in the frequency of Foxp3+ CD25+ Tregs with a corresponding increase in Foxp3-CD25+ effector T cells
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• CD4 T cells exhibit an activated phenotype
• mice develop systemic T helper type 2 immunity
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• marker analysis indicates impaired keratinocyte differentiation
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• loss of hypodermal fat
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• normal numbers born
• normal phenotype and survive to wk 5
• growth normal
• breathe and eat normally
• normal activity
• not diabetic to wk 8
• all die at age 5-11 wks
• drop in activity 2-3 days before death and weight loss
• noncardiac muscle normal
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• by 6 wks, collagen levels, ANF and beta-myosin heavy chain levels are increased in hearts
• increased sensitivity of cardiomyocytes to hypoxia
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• cardiomyocytes appear more separated from each other
• reduction in cardiomyocyte volume
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• atria enlarge by 6 wks and massively inflated at death
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• from 2-4 weeks, hearts became progressively smaller in relative terms but otherwise were normal
• by 6 weeks hearts were much smaller with reduced muscle mass due to smaller cardiomyocytes
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• muscle mass of hearts is significantly reduced
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• right ventricle is significantly enlarged by 6 weeks of age
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• by 6 weeks
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• by 6 weeks
• extremely thin by death
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• by 8 weeks of age, exhibit an increase in Z-line thickness, a feature of dilated cardiomyopathy
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• echocardiograms at 5-6 weeks revealing development of heart failure
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• reduced fractional shortening and ejection fraction
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• by 6 weeks
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• observe a significant reduction in body weight 2-3 days before mutants die
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• cardiomyocytes appear more separated from each other
• reduction in cardiomyocyte volume
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• muscle mass of hearts is significantly reduced
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• by 6 weeks
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• by 8 weeks of age, exhibit an increase in Z-line thickness, a feature of dilated cardiomyopathy
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• reduced fractional shortening and ejection fraction
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• thicker Z-line by 8 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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