All Phenotypes Nck2<tm1Paw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nck2^tm1Paw/Nck2^tm1Paw	involves: 129/Ola * ICR	MGI:2674269
cn2	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm1Paw/Nck2^tm3Paw Tg(Nes-cre)1Kln/0	involves: C57BL/6 * SJL	MGI:3769794
cx3	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm1Paw/Nck2^tm1Paw	involves: 129/Ola * ICR	MGI:2674277

Allelic Composition	Nck2^tm1Paw/Nck2^tm1Paw
Genetic Background	involves: 129/Ola * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nck2^tm1Paw mutation (1 available); any Nck2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:83956 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:129166 )

• mice die within a few days of birth with empty stomachs likely due to suckling defects

• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity

nervous system

abnormal axon guidance ( J:129166 )

• axons aberrantly re-cross the midline of the grey matter of the spinal cord

• interneurons aberrantly re-cross the midline of the spinal cord

abnormal brain commissure morphology ( J:129166 )

• reduced development of the posterior commissure noted at 12 weeks of age

abnormal spinal cord grey matter morphology ( J:129166 )

• axons aberrantly re-cross the midline of the grey matter of the spinal cord

abnormal spinal cord dorsal column morphology ( J:129166 )

• mice exhibit a shallow dorsal funiculus and does not widen in adulthood compared to controls

abnormal central pattern generator function ( J:129166 )

• mice exhibit synchronous firing of bilateral ventral motor neurons

behavior/neurological

ataxia ( J:129166 )

• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity

abnormal gait ( J:129166 )

• mice exhibit a hoping gait that is maintained to adulthood

growth/size/body

decreased body size ( J:129166 )

• one mouse survived to P12 and was small, severely ataxic, and its hindlimbs respond to stimulation with rhythmic extension/flexion seizure-like activity

cellular

abnormal axon guidance ( J:129166 )

• axons aberrantly re-cross the midline of the grey matter of the spinal cord

• interneurons aberrantly re-cross the midline of the spinal cord

Allelic Composition	Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm1Paw/Nck2^tm1Paw
Genetic Background	involves: 129/Ola * ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nck1^tm1Paw mutation (2 available); any Nck1 mutation (40 available)
Nck2^tm1Paw mutation (1 available); any Nck2 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:83956 )

• no double homozygous mutant mice born

• double homozygotes present at Mendelian ratios at E8.5

• by E10.5 double homozygotes reduced to one third of expected

• no double homozygous mutant embryos by E12.5

cellular

abnormal cell physiology ( J:83956 )

• actin fiber abnormalities

• decreased fibroblast mobility

embryo

abnormal developmental patterning ( J:83956 )

• deficient axial rotation

abnormal embryonic tissue morphology ( J:83956 )

abnormal neural tube morphology ( J:83956 )

incomplete rostral neuropore closure ( J:83956 )

• neural tube closure to level of otic vesicles but no further anteriorly

wavy neural tube ( J:83956 )

notochord degeneration ( J:83956 )

• initial development is normal at the 2 to 4 somite stage

• degenerates rapidly after initial formation

abnormal extraembryonic tissue morphology ( J:83956 )

abnormal allantois morphology ( J:83956 )

• growing toward headfold structures

dilated allantois ( J:83956 )

• allantois misshapen and balloon like

failure of chorioallantoic fusion ( J:83956 )

• lack of chorioallantoic fusion

• due to misshapen allantois

• failure to develop definitive embryonic circulation

nervous system

abnormal neural tube morphology ( J:83956 )

incomplete rostral neuropore closure ( J:83956 )

• neural tube closure to level of otic vesicles but no further anteriorly

wavy neural tube ( J:83956 )

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