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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Or8a1+
wild type
MGI:2664408
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Or8a1tm37(Or10j5*,Gnas*)Mom/Or8a1+ B6;129P2-Or8a1tm37(Or10j5*,Gnas*)Mom/MomJ MGI:5788666
ht2
 		Or8a1tm39(Gnas*)Mom/Or8a1+ B6;129P2-Or8a1tm39(Gnas*)Mom/MomJ MGI:5788650
ht3
 		Or8a1tm26Mom/Or8a1+ involves: 129P2/OlaHsd * C57BL/6 MGI:3694124
cx4
 		Or8a1tm25Mom/Or8a1+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0 		involves: 129 * C3H/HeJ * C57BL/6J MGI:5811882
cx5
 		Ebf2tm1Reed/Ebf2+
Or8a1tm26Mom/Or8a1+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ MGI:3714646
cx6
 		Or8a1tm10Mom/Or8a1+
Or8a1btm4Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694133
cx7
 		Or8a1tm2Mom/Or8a1+
Or8a1btm6Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694130
cx8
 		Or8a1tm1Mom/Or8a1+
Or8a1btm1(Or8a1)Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694128
cx9
 		Or8a1tm11(Or8a1b)Mom/Or8a1+
Or8a1btm1(Or8a1)Mom/Or8a1b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:3694125


Genotype
MGI:5788666
ht1
Allelic
Composition		 Or8a1tm37(Or10j5*,Gnas*)Mom/Or8a1+
Genetic
Background		 B6;129P2-Or8a1tm37(Or10j5*,Gnas*)Mom/MomJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm37(Or10j5*,Gnas*)Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
abnormal olfactory receptor morphology ( J:233447 )
• despite the change in G-protein usage, the substitution of coding sequence causes axons of olfactory sensory neurons expressing this allele to project to an area anterior of where OLFR151 axons normally project to an area where OLFR16 axons usually project, consistent with the expressed receptor determining axonal identity
decreased olfactory sensory neuron number ( J:233447 )
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient
impaired olfaction ( J:233447 )
• performated patch-clamp recordings of 17 olfactory sensory neurons expressing this allele found only 13 responded to IBMX+forskolin and none responded to lyral, acetopohenone, or a mixture of odorants that normally activates 66% of randomly patched olfactory sensory neurons, showing that basal signalling of the olfactory receptor is required for spontaneous olfactory sensory neuron spiking

craniofacial
abnormal olfactory receptor morphology ( J:233447 )
• despite the change in G-protein usage, the substitution of coding sequence causes axons of olfactory sensory neurons expressing this allele to project to an area anterior of where OLFR151 axons normally project to an area where OLFR16 axons usually project, consistent with the expressed receptor determining axonal identity
decreased olfactory sensory neuron number ( J:233447 )
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

growth/size/body
abnormal olfactory sensory neuron morphology ( J:233447 )
abnormal olfactory receptor morphology ( J:233447 )
• despite the change in G-protein usage, the substitution of coding sequence causes axons of olfactory sensory neurons expressing this allele to project to an area anterior of where OLFR151 axons normally project to an area where OLFR16 axons usually project, consistent with the expressed receptor determining axonal identity
decreased olfactory sensory neuron number ( J:233447 )
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

nervous system
abnormal olfactory receptor morphology ( J:233447 )
• despite the change in G-protein usage, the substitution of coding sequence causes axons of olfactory sensory neurons expressing this allele to project to an area anterior of where OLFR151 axons normally project to an area where OLFR16 axons usually project, consistent with the expressed receptor determining axonal identity
decreased olfactory sensory neuron number ( J:233447 )
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

respiratory system
abnormal olfactory receptor morphology ( J:233447 )
• despite the change in G-protein usage, the substitution of coding sequence causes axons of olfactory sensory neurons expressing this allele to project to an area anterior of where OLFR151 axons normally project to an area where OLFR16 axons usually project, consistent with the expressed receptor determining axonal identity
decreased olfactory sensory neuron number ( J:233447 )
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient




Genotype
MGI:5788650
ht2
Allelic
Composition		 Or8a1tm39(Gnas*)Mom/Or8a1+
Genetic
Background		 B6;129P2-Or8a1tm39(Gnas*)Mom/MomJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm39(Gnas*)Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
taste/olfaction
decreased olfactory sensory neuron number ( J:233447 )
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

craniofacial
decreased olfactory sensory neuron number ( J:233447 )
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

nervous system
decreased olfactory sensory neuron number ( J:233447 )
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

growth/size/body
abnormal olfactory receptor morphology ( J:233447 )
decreased olfactory sensory neuron number ( J:233447 )
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient

respiratory system
decreased olfactory sensory neuron number ( J:233447 )
• the inclusion of a constitutively active GNAS rescues only a few DRY motif-deficient olfactory sensory neurons from loss as assessed at 21 days of age
• although expression of consitutively active GNAS restores the axonal projections to the bulb in these DRY mutant motif receptors, there are fewer than normal olfactory sensory neurons surviving that express this allele, and glomerular formation is therefore inefficient




Genotype
MGI:3694124
ht3
Allelic
Composition		 Or8a1tm26Mom/Or8a1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1tm26Mom mutation (3 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:90716 )
• glomeruli in heterozygotes containing the C57BL/6 pseudogene are reduced from ~50 um diameter to ~32 um in diameter
abnormal sensory neuron innervation pattern ( J:90716 )
• there is ~50% reduction of axonal inputs innervating glomeruli; all axons are of Olfr151




Genotype
MGI:5811882
cx4
Allelic
Composition		 Or8a1tm25Mom/Or8a1+
Omptm1(tTA)Gogo/Omp+
Tg(tetO-APPSwInd)Dbo/0
Genetic
Background		 involves: 129 * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omptm1(tTA)Gogo mutation (1 available); any Omp mutation (26 available)
Or8a1tm25Mom mutation (6 available); any Or8a1 mutation (69 available)
Tg(tetO-APPSwInd)Dbo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

growth/size/body
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

nervous system
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

respiratory system
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

taste/olfaction
decreased olfactory sensory neuron number ( J:199798 )
• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number
• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli




Genotype
MGI:3714646
cx5
Allelic
Composition		 Ebf2tm1Reed/Ebf2+
Or8a1tm26Mom/Or8a1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2tm1Reed mutation (0 available); any Ebf2 mutation (32 available)
Or8a1tm26Mom mutation (3 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

craniofacial
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

respiratory system
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

taste/olfaction
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb

growth/size/body
abnormal olfactory sensory neuron morphology ( J:122275 )
• most olfactory receptor neurons project to multiple more ventral glomeruli
• P2 olfactory receptor neurons extend much shorter axons and project into the ventral region of the bulb




Genotype
MGI:3694133
cx6
Allelic
Composition		 Or8a1tm10Mom/Or8a1+
Or8a1btm4Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm4Mom mutation (1 available); any Or8a1b mutation (35 available)
Or8a1tm10Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:90716 )
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character
abnormal olfactory neuron innervation pattern ( J:90716 )
• Hyb J axons form distinct glomeruli that are not Olfr151 or Olfr160 in character




Genotype
MGI:3694130
cx7
Allelic
Composition		 Or8a1tm2Mom/Or8a1+
Or8a1btm6Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm6Mom mutation (4 available); any Or8a1b mutation (35 available)
Or8a1tm2Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory neuron innervation pattern ( J:90716 )
• Olfr151 and Olfr160 axons only intermingle to a small extent; atypical glomeruli are formed in which some co-mingling of Olfr151tm2Momaxons with both Olfr151 and Olfr160 axons occurs, but Olfr151tm2Momaxons are shared between glomeruli




Genotype
MGI:3694128
cx8
Allelic
Composition		 Or8a1tm1Mom/Or8a1+
Or8a1btm1(Or8a1)Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm1(Or8a1)Mom mutation (3 available); any Or8a1b mutation (35 available)
Or8a1tm1Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:90716 )
• Hyb A axons co-converge with Olfr160tm6Mom axons onto the same glomeruli, but axons segregate into separate compartments within the glomeruli




Genotype
MGI:3694125
cx9
Allelic
Composition		 Or8a1tm11(Or8a1b)Mom/Or8a1+
Or8a1btm1(Or8a1)Mom/Or8a1b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or8a1btm1(Or8a1)Mom mutation (3 available); any Or8a1b mutation (35 available)
Or8a1tm11(Or8a1b)Mom mutation (1 available); any Or8a1 mutation (69 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal olfactory bulb morphology ( J:90716 )
• Olfr160 (M72) glomeruli are positioned more posterior and medial to the corresponding glomeruli in control mice, while Olfr151 (M71) glomeruli are slightly more anterior and lateral to the normal location




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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory