Phenotypes associated with this allele

• Allele Symbol: Kiss1⁺
• Allele Name: wild type
• Allele ID: MGI:2663986
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kiss1^tm1.1(cre/EGFP)Stei/Kiss1^+	involves: 129S6/SvEvTac * C57BL/6NCr	MGI:5449629
cn2	Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor^+ Kiss1^tm1.1(cre)Uboe/Kiss1^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J	MGI:5052335
cn3	Kiss1^tm1.1(cre)Uboe/Kiss1^+ Nhlh2^tm2Thbr/Nhlh2^tm2Thbr	involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:5524042
cn4	Gt(ROSA)26Sor^tm1(HBEGF)Awai/Gt(ROSA)26Sor^+ Kiss1^tm1.1(cre)Uboe/Kiss1^+	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL	MGI:5052334
cn5	Esr1^tm1.2Awo/Esr1^tm1.2Awo Kiss1^tm1.1(cre)Uboe/Kiss1^+	involves: 129S6/SvEvTac * C57BL/6 * SJL	MGI:4878879

Genotype
MGI:5449629

ht1

• Allelic Composition: Kiss1^{tm1.1(cre/EGFP)Stei}/Kiss1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:178519 )

♀N • Kiss1 neurons (neurons labeling for GFP) in the arcuate nucleui (ARC) of ovariectomized adult females express a hyperpolarization induced cation current (h current) and a transient Ca²⁺ current (T-type current) which are pacemaker currents, mRNA expression of Cnga1 (HCN) and Cacna1g (voltage-dependent calcium channel, T type, alpha 1G subunit) which underlie pacemaker currents, and show NMDA-induced burst firing activity; these data corroborate findings in the ARC of guinea pigs

Genotype
MGI:5052335

cn2

• Allelic Composition: Gt(ROSA)26Sor^tm1(DTA)Riet/Gt(ROSA)26Sor⁺; Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * C57BL/6J

mortality/aging

mortality/aging ( J:173936 )

N • mice are viable

reproductive system

reproductive system phenotype ( J:173936 )

N • female mice exhibit normal onset of puberty, ovalutory cyclicity, and fertile

decreased ovary weight ( J:173936 )

♀ • at P20

abnormal vagina development ( J:173936 )

♀ • female mice exhibit slightly prolonged phases of cornification compared with wild-type mice

growth/size/body

increased body weight ( J:173936 )

• slightly increased in female mice between P31 and P46

endocrine/exocrine glands

decreased ovary weight ( J:173936 )

♀ • at P20

Genotype
MGI:5524042

cn3

• Allelic Composition: Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺; Nhlh2^tm2Thbr/Nhlh2^tm2Thbr
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * C57BL/6J

reproductive system

reproductive system phenotype ( J:199640 )

♀N • mice exhibit normal uteri weight

growth/size/body

growth/size/body region phenotype ( J:199640 )

N • mice exhibit normal weight

adipose tissue

adipose tissue phenotype ( J:199640 )

N • mice exhibit normal visceral fat depots

Genotype
MGI:5052334

cn4

• Allelic Composition: Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺; Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * SJL

reproductive system

abnormal estrous cycle ( J:173936 )

♀ • in diphtheria-treated mice

prolonged diestrus ( J:173936 )

♀ • in diphtheria-treated mice

prolonged estrus ( J:173936 )

♀ • in diphtheria-treated mice

female infertility ( J:173936 )

♀ • in diphtheria-treated mice

nervous system

decreased neuron number ( J:173936 )

• diphtheria-treated mice exhibit ablation of Kiss1+ neurons

Genotype
MGI:4878879

cn5

• Allelic Composition: Esr1^tm1.2Awo/Esr1^tm1.2Awo; Kiss1^{tm1.1(cre)Uboe}/Kiss1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

reproductive system

reproductive system phenotype ( J:167285 )

♂N • testis weight in adult males is not different from wild-type

absent corpus luteum ( J:167285 )

♀ • in P35 ovaries, corpora lutea are completely absent

♀ • in adult ovaries, few or no corpora lutea are observed

ovary cyst ( J:167285 )

♀ • ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

♀ • adult ovaries also show numerous large follicular cysts

early vaginal opening ( J:167285 )

♀ • observed significantly earlier than in wild-type (13 vs 29 days postnatal)

abnormal estrous cycle ( J:167285 )

♀ • females exhibit prolonged period (weeks or months) of persistent vaginal cornification

♀ • in some animals, isolated "breakthrough" cycles occur followed by more periods of prolonged acyclicity

prolonged diestrus ( J:167285 )

♀ • prolonged period of persistent vaginal cornification is followed by persistent diestrus state

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167285 )

N • serum luteinizing hormone (LH) levels in adult castrated (cx) males is not different from cx wil-type males; at P35 serum LH levels are similar in mutant and wild-type males

decreased circulating luteinizing hormone level ( J:167285 )

• in absence of ovarian restraint (after ovariectomy), LH secretion is greatly reduced in adult females compared to ovariectomized wild-type females

increased circulating luteinizing hormone level ( J:167285 )

• serum LH concentration is 6-7-fold higher at P15 than in age-matched wild-type; levels remain elevated at P25, then decline to wild-type levels by P35

endocrine/exocrine glands

absent corpus luteum ( J:167285 )

♀ • in P35 ovaries, corpora lutea are completely absent

♀ • in adult ovaries, few or no corpora lutea are observed

ovary cyst ( J:167285 )

♀ • ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

♀ • adult ovaries also show numerous large follicular cysts

growth/size/body

ovary cyst ( J:167285 )

♀ • ovaries from P25 and P35 animals contain numerous cysts

ovarian follicular cyst ( J:167285 )

♀ • adult ovaries also show numerous large follicular cysts