Phenotypes associated with this allele
nervous system
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• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice
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• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice
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homeostasis/metabolism
cellular
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• MPTP-treated mice exhibit reduced numbers of tyrosine hydroxylase (TH)+ neurons and GFP+ TH+ neurons in the substantia nigra pars compacta (SNpc) and ventral tegmental area (VTA) compared with similarly treated wild-type mice
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• the percentage of GFP+ glyco-Slc6a3 (DAT)+ neurons is higher than in control mice
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nervous system
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• when tamoxifen is given on E15, choroid epithelial cells as well as the entire structures appear unaltered in size; however, at P7, fourth ventricular choroid plexus is much smaller (decreased rostrocaudally, not lateral to medial) compared to controls
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• with tamoxifen induction on E9 of gestation, the four choroid plexuses in the forebrain (including the third ventricular choroid plexus anlage) and hindbrain are virtually absent in E13 embryos; in some embryos a small remnant is found caudally but this tissue is not transthyretin-positive as expected
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mortality/aging
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• all mutants die at birth
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nervous system
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• proliferating neuroblasts are increased in number in floor plate neuroepithelium at E12.5
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• isthmus is reduced in size and thickness at E18.5
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• posterior tectum is reduced in size and thickness at E18.5
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• tegmentum is enlarged at E18.5
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cellular
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• proliferating neuroblasts are increased in number in floor plate neuroepithelium at E12.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf7tm3(cre)Tmj mutation
(0 available);
any
Gdf7 mutation
(16 available)
Otx2tm6Asim mutation
(1 available);
any
Otx2 mutation
(50 available)
Tg(CAG-cat,-EGFP)1Rbns mutation
(1 available)
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nervous system
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• by E13, a dramatic decrease in hindbrain choroid plexus size is detected relative to controls
• at P2 and adult ages, the choroid plexus is much smaller than in controls
• increased apoptosis (both late and early, overall a 2.5 fold increase) is detected in the hindbrain choroid at E13.5; less proliferating cells are also detected in the plexus compared to controls
• blood vessels form at normal density, although they appear slightly more disorganized in the hindbrain choroid plexus region
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• at E13, an increase in apical PH3-positive cells is observed (30%) with a slight decrease in basal progenitors (10%); a 40% decrease in PH3-ve cells at the apical surface is detected in the cerebral cortex at P16
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• total CSF protein concentration is increased by 30% and 60% at E13 and E14 relative to control values; at E12, no change is detected
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Analysis Tools