Gdf7^tm3(cre)Tmj
Targeted Allele Detail

Summary

• Symbol: Gdf7^tm3(cre)Tmj
• Name: growth differentiation factor 7; targeted mutation 3, Thomas M Jessell
• MGI ID: MGI:3588567
• Synonyms: Gdf7cre, Gdf7-cre
• Gene: Gdf7 Location: Chr12:8347918-8351954 bp, - strand Genetic Position: Chr12, 3.85 cM
• Alliance: Gdf7^tm3(cre)Tmj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60594
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gdf7^tm3(cre)Tmj expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gdf7 (MGI:95690)

• Mutation details: Cre recombinase cDNA and an FRT-flanked neo was inserted downstream of the coding sequence such that expression of cre would be directed by Gdf7 regulatory elements. Expression was shown to recapitulate roof-plate-specific expression of Gdf7. (J:60594)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gdf7 (mouse) Summary of all recombinase alleles driven by Gdf7. Alliance mouse Gdf7 gene page

Expression

In Mice Carrying this Mutation:

11 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf7 Mutation: 16 strains or lines available

References

• Original: J:60594 Lee KJ, et al., Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification [see comments]. Nature. 2000 Feb 17;403(6771):734-40
• All: 6 reference(s)