Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npy2rtm1Pern mutation
(1 available);
any
Npy2r mutation
(30 available)
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behavior/neurological
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• 50 mg/kg and 60 mg/kg of sodium pentobarbital induces a greater loss of righting reflex (LORR) than in wild-type mice (135% and143%, respectively by dose)
• however, righting response is no different from that of wild-type mice after treatment with ketamin
• NPY-induced sensitization to LORR induced by pentobarbital or ketamine is increased compared to in wild-type mice
• NPY-induced sensitization to LORR induced by pentobarbital greater when NPY is injected into the posterior hypothalamus versus the lateral hypothalamus
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• mice sleep longer than wild-type mice following treatment with pentobarbital
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npy2rtm1Pern mutation
(1 available);
any
Npy2r mutation
(30 available)
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adipose tissue
behavior/neurological
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• mutants show an attenuated response to leptin, exhibiting only a 15.2% reduction in food intake compared to 30.5% decrease in wild-type mice, 12 hours after leptin administration, however no differences in food intake are observed after 45 hours
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• mean 12% increase in 24-hour food consumption
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• reduction in activity during both dark and light phases
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cardiovascular system
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• increase shows statistical significance at night
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growth/size/body
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• males and females fed a normal-fat diet are mildly overweight
• a high-fat diet leads to a more substantial increase in body weight, especially in females
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homeostasis/metabolism
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npy2rtm1Pern mutation
(1 available);
any
Npy2r mutation
(30 available)
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behavior/neurological
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• mice drink less 3% and 6% ethanol solution than wild-type mice
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• water consumption is increased relative to wild-type mice
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behavior/neurological
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• authors state that mice display a similar sensitivity to loss of righting response induced by pentobarbital as
Npy1rtm1Pern homozygous mice
• mice display a decrease in loss of righting response to ketamin-sedation compared to wild-type mice
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homeostasis/metabolism
growth/size/body
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• starting at week 9, female mice weigh less than Lepob homozygotes
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behavior/neurological
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• impaired righting response caused by pentobarbital or ketamin is the same as in wild-type mice
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