Npy2r^tm1Pern
Targeted Allele Detail

Summary

• Symbol: Npy2r^tm1Pern
• Name: neuropeptide Y receptor Y2; targeted mutation 1, Patrick Ernfors
• MGI ID: MGI:2654580
• Synonyms: Npy2r^-, Y2^-
• Gene: Npy2r Location: Chr3:82445690-82455391 bp, - strand Genetic Position: Chr3, 36.49 cM
• Alliance: Npy2r^tm1Pern page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57961
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a lacZ-neo cassette into a protein-coding exon via homologous recombination. Absence of gene expression was confirmed by Northern blot analysis of hypothalamus RNA. (J:57961, J:109294)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npy2r Mutation: 30 strains or lines available

References

• Original: J:57961 Naveilhan P, et al., Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor. Nat Med. 1999 Oct;5(10):1188-93
• All: 11 reference(s)