All Phenotypes Rag1<tm1Bal> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rag1^tm1Bal
targeted mutation 1, David Baltimore
MGI:2448994

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Lat^tm2.1Mal/Lat^tm2.1Mal Rag1^tm1Bal/Rag1^tm1Bal	involves: 129S2/SvPas * 129S4/SvJae	MGI:3770648
cx2	Lat^tm1.1Mal/Lat^tm1.1Mal Rag1^tm1Bal/Rag1^tm1Bal	involves: 129S2/SvPas * 129S4/SvJae	MGI:3770649
cx3	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb	involves: 129S4/SvJae * 129S8/SvEv	MGI:3689310
cx4	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0	involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL	MGI:3689309
cx5	Rag1^tm1Bal/Rag1^tm1Bal Tg(TcraTcrb)1100Mjb/?	involves: 129S4/SvJae * C57BL/6	MGI:3783835
cx6	C1galt1^ptl1/C1galt1^ptl1 Rag1^tm1Bal/Rag1^tm1Bal	involves: 129S4/SvJae * C57BL/6	MGI:3723642
cx7	Rag1^tm1Bal/Rag1^tm1Bal Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl	involves: 129/Sv * C57BL/6	MGI:3053736

Allelic Composition	Lat^tm2.1Mal/Lat^tm2.1Mal Rag1^tm1Bal/Rag1^tm1Bal
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat^tm2.1Mal mutation (0 available); any Lat mutation (9 available)
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased platelet aggregation ( J:125744 )

• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen

abnormal platelet dense granule physiology ( J:125744 )

• platelet-dense granule secretion is absent in response to low doses of the clotting agonist

homeostasis/metabolism

decreased platelet aggregation ( J:125744 )

• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen

abnormal platelet dense granule physiology ( J:125744 )

• platelet-dense granule secretion is absent in response to low doses of the clotting agonist

abnormal thrombosis ( J:125744 )

• platelets are unable to form a multilayered thrombi on collagen coated surfaces

Allelic Composition	Lat^tm1.1Mal/Lat^tm1.1Mal Rag1^tm1Bal/Rag1^tm1Bal
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lat^tm1.1Mal mutation (0 available); any Lat mutation (9 available)
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased platelet aggregation ( J:125744 )

• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen

• however, platelets do aggregate in response to low doses of thrombin

abnormal platelet dense granule physiology ( J:125744 )

• platelet-dense granule secretion is absent in response to low doses of the clotting agonist

homeostasis/metabolism

decreased platelet aggregation ( J:125744 )

• platelets do not aggregate in response to low doses of a snake venom clotting agonist or collagen

• however, platelets do aggregate in response to low doses of thrombin

abnormal platelet dense granule physiology ( J:125744 )

• platelet-dense granule secretion is absent in response to low doses of the clotting agonist

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

arrested T cell differentiation ( J:113270 )

• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

hematopoietic system

arrested T cell differentiation ( J:113270 )

• complete arrest at the double negative cell stage similar to mice homozygous for the Rag1 mutation alone

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Vav1^tm2Tyb/Vav1^tm2Tyb Tg(TcrAND)53Hed/0
Genetic Background	involves: 129S4/SvJae * 129S8/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Tg(TcrAND)53Hed mutation (2 available)
Vav1^tm2Tyb mutation (0 available); any Vav1 mutation (58 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:113270 )

• reduced percentage of CD4+ cells compared to mice wild-type for Vav1

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Tg(TcraTcrb)1100Mjb/?
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta T cell number ( J:133645 )

• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:133645 )

• many of the CD4 T cells express the transgenic TCR alpha chain

decreased CD4-positive, alpha-beta T cell number ( J:133645 )

• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:133645 )

• OVA-specific CD8 T cells make up 97% of cells found in lymph nodes and 24% of cells in spleen

abnormal CD4-positive, alpha beta T cell morphology ( J:133645 )

• many of the CD4 T cells express the transgenic TCR alpha chain

decreased CD4-positive, alpha-beta T cell number ( J:133645 )

• CD4 T cells make up less than 1% of total cells found in lymph nodes or spleen

Allelic Composition	C1galt1^ptl1/C1galt1^ptl1 Rag1^tm1Bal/Rag1^tm1Bal
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C1galt1^ptl1 mutation (0 available); any C1galt1 mutation (24 available)
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Premature death and kidney disease in C1galt1^ptl1/C1galt1^ptl1 and C1galt1^ptl1/C1galt1^ptl1 Rag1^tm1Bal/Rag1^tm1Bal mice

mortality/aging

premature death ( J:115272 )

• mutants become ill, develop kidney disease and most are moribund by 200 days

renal/urinary system

increased urine protein level ( J:115272 )

kidney inflammation ( J:115272 )

• extensive inflammatory infiltration

abnormal kidney morphology ( J:115272 )

• renal lesions

decreased renal glomerulus number ( J:115272 )

• loss of glomeruli

abnormal renal tubule morphology ( J:115272 )

• tubular disorganization

hematopoietic system

thrombocytopenia ( J:115272 )

• thrombocytopenia

increased mean platelet volume ( J:115272 )

• high platelet volume

homeostasis/metabolism

increased urine protein level ( J:115272 )

immune system

kidney inflammation ( J:115272 )

• extensive inflammatory infiltration

Allelic Composition	Rag1^tm1Bal/Rag1^tm1Bal Tnfrsf1a^tm1.1Gkl/Tnfrsf1a^tm1.1Gkl
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag1^tm1Bal mutation (5 available); any Rag1 mutation (120 available)
Tnfrsf1a^tm1.1Gkl mutation (1 available); any Tnfrsf1a mutation (47 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

liver/biliary system

liver inflammation ( J:92470 )

• liver inflammation is seen by 3-4 weeks of age and persists throughout adulthood

• no change in the severity of liver inflammation is seen compared to Tnfrsf1a^tm1Gkl in homozygotes

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