All Phenotypes Ikzf1<tm1(Pax5)Mbu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu	involves: 129P2/OlaHsd * C57BL/6	MGI:3701095
cn2	Ikzf1^tm1(Pax5)Mbu/Ikzf1⁺ Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3701081
cn3	Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2653526

Allelic Composition	Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1^tm1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:80815 )

• thymocytes only develop postnatally

abnormal B cell number ( J:80815 )

• CD19+ B cells are absent from spleen and bone marrow

abnormal dendritic cell morphology ( J:80815 )

• CD11c+ dendritic cells are absent from bone marrow and spleen

immune system

abnormal T cell differentiation ( J:80815 )

• thymocytes only develop postnatally

abnormal B cell number ( J:80815 )

• CD19+ B cells are absent from spleen and bone marrow

abnormal dendritic cell morphology ( J:80815 )

• CD11c+ dendritic cells are absent from bone marrow and spleen

Allelic Composition	Ikzf1^tm1(Pax5)Mbu/Ikzf1⁺ Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikzf1^tm1(Pax5)Mbu mutation (0 available); any Ikzf1 mutation (30 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:118111 )

• immature T cell lymphomas develop with shorter latency than in Igh^tm1(PAX5)Mbu homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:118111 )

• immature T cell lymphomas develop with shorter latency than in Igh^tm1(PAX5)Mbu homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

increased early pro-B cell number ( J:80815 )

• there is 17-fold expansion of early pro-B cells, until day 23

abnormal T cell differentiation ( J:80815 )

• numbers of double positive thymocytes is reduced, while double positive numbers are increased relative to controls

arrested T cell differentiation ( J:80815 )

• partial block at DN3 stage is observed

increased B cell number ( J:80815 )

• upon induction of transgene, bone marrow contains ~9 times more B lmphocytes compared to control

immune system

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

increased early pro-B cell number ( J:80815 )

• there is 17-fold expansion of early pro-B cells, until day 23

abnormal T cell differentiation ( J:80815 )

• numbers of double positive thymocytes is reduced, while double positive numbers are increased relative to controls

arrested T cell differentiation ( J:80815 )

• partial block at DN3 stage is observed

increased B cell number ( J:80815 )

• upon induction of transgene, bone marrow contains ~9 times more B lmphocytes compared to control

endocrine/exocrine glands

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

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