Phenotypes associated with this allele

• Allele Symbol: Ikzf1^tm1(Pax5)Mbu
• Allele Name: targeted mutation 1, Meinrad Busslinger
• Allele ID: MGI:2447783
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu	involves: 129P2/OlaHsd * C57BL/6	MGI:3701095
cn2	Ikzf1^tm1(Pax5)Mbu/Ikzf1^+ Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3701081
cn3	Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2653526

Genotype
MGI:3701095

hm1

• Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:80815 )

• thymocytes only develop postnatally

abnormal B cell number ( J:80815 )

• CD19+ B cells are absent from spleen and bone marrow

abnormal dendritic cell morphology ( J:80815 )

• CD11c+ dendritic cells are absent from bone marrow and spleen

immune system

abnormal T cell differentiation ( J:80815 )

• thymocytes only develop postnatally

abnormal B cell number ( J:80815 )

• CD19+ B cells are absent from spleen and bone marrow

abnormal dendritic cell morphology ( J:80815 )

• CD11c+ dendritic cells are absent from bone marrow and spleen

Genotype
MGI:3701081

cn2

• Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1⁺; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased T cell derived lymphoma incidence ( J:118111 )

• immature T cell lymphomas develop with shorter latency than in Igh^tm1(PAX5)Mbu homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:118111 )

• immature T cell lymphomas develop with shorter latency than in Igh^tm1(PAX5)Mbu homozygotes

hematopoietic system

increased T cell derived lymphoma incidence ( J:118111 )

• immature T cell lymphomas develop with shorter latency than in Igh^tm1(PAX5)Mbu homozygotes

immune system

increased T cell derived lymphoma incidence ( J:118111 )

• immature T cell lymphomas develop with shorter latency than in Igh^tm1(PAX5)Mbu homozygotes

Genotype
MGI:2653526

cn3

• Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

hematopoietic system

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

increased early pro-B cell number ( J:80815 )

• there is 17-fold expansion of early pro-B cells, until day 23

abnormal T cell differentiation ( J:80815 )

• numbers of double positive thymocytes is reduced, while double positive numbers are increased relative to controls

arrested T cell differentiation ( J:80815 )

• partial block at DN3 stage is observed

increased B cell number ( J:80815 )

• upon induction of transgene, bone marrow contains ~9 times more B lmphocytes compared to control

immune system

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

increased early pro-B cell number ( J:80815 )

• there is 17-fold expansion of early pro-B cells, until day 23

abnormal T cell differentiation ( J:80815 )

• numbers of double positive thymocytes is reduced, while double positive numbers are increased relative to controls

arrested T cell differentiation ( J:80815 )

• partial block at DN3 stage is observed

increased B cell number ( J:80815 )

• upon induction of transgene, bone marrow contains ~9 times more B lmphocytes compared to control

endocrine/exocrine glands

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23