Ikzf1^tm1(Pax5)Mbu
Targeted Allele Detail

Summary

• Symbol: Ikzf1^tm1(Pax5)Mbu
• Name: IKAROS family zinc finger 1; targeted mutation 1, Meinrad Busslinger
• MGI ID: MGI:2447783
• Synonyms: Ik^neo
• Gene: Ikzf1 Location: Chr11:11634980-11722926 bp, + strand Genetic Position: Chr11, 7.02 cM
• Alliance: Ikzf1^tm1(Pax5)Mbu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80815
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A construct containing a floxed neo cassette, Pax5 gene, and GFP gene was inserted into the Znfn1a1 locus upstream of the translation initiation codon in exon 2. Western blot analysis using antibodies against C-terminal Znfn1a1 sequences did not detect protein product in thymocytes from homozygous mutant animals. Trace amounts of Pax5 protein was detected in thymocytes. (J:80815)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf1 Mutation: 31 strains or lines available

References

• Original: J:80815 Souabni A, et al., Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity. 2002 Dec;17(6):781-93
• All: 6 reference(s)