Phenotypes associated with this allele
Allelic
Composition |
Yy1tm1Yshi/Yy1tm1Yshi
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Genetic
Background |
either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yy1tm1Yshi mutation
(0 available);
any
Yy1 mutation
(34 available)
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mortality/aging
embryo
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• implantation occurs, but embryos fail to differentiate thereafter
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Allelic
Composition |
Yy1tm1Yshi/Yy1+
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Genetic
Background |
involves: 129S4/SvJae * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yy1tm1Yshi mutation
(0 available);
any
Yy1 mutation
(34 available)
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embryo
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• incomplete penetrance, seen in ~25% of mixed strain heterozygotes
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growth/size/body
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• incomplete penetrance, seen in ~25% of mixed strain heterozygotes
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nervous system
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• incomplete penetrance, seen in ~25% of mixed strain heterozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yy1tm1Yshi mutation
(0 available);
any
Yy1 mutation
(34 available)
Yy1tm2Yshi mutation
(1 available);
any
Yy1 mutation
(34 available)
|
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mortality/aging
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• about 25% of mice die between E13.5 and E14.5 and another 25% die between E16.5 and E19.5
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• all mice that survive until birth die within 48 hours
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respiratory system
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• pups isolated at E19.5 fail to inflate their lungs despite visible breathing efforts
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cellular
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• MEFs proliferate slower and produce smaller colonies
• Cre mediated recombination of the floxed allele produced a decrease in colony number and size and stopped proliferation by blocking cytokinesis
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homeostasis/metabolism
integument
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• live born pups appear pale
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Zp3-cre)93Knw mutation
(2 available)
Yy1tm1Yshi mutation
(0 available);
any
Yy1 mutation
(34 available)
Yy1tm2.1Yshi mutation
(0 available);
any
Yy1 mutation
(34 available)
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reproductive system
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• oocytes rarely grow larger than 50 um in diameter, indicating arrested oocyte growth
• oocyte-specific expression of Gdf9 and Bmp15 is nearly undetectable
• oocytes exhibit altered levels of several oocyte-specific factors, including Pou5f1, Figla, Lhx8, Oosp1, and Sohlh2
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• secondary follicles often contain a degenerating oocyte
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• no mature follicles are observed
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• percent of follicles in the primary stage is significantly higher than in controls (83% versus 20%)
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• no multilayered, antral follicles or Graafian follicles are observed
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• ovarian follicle maturation is halted; no post-secondary follicles are observed
• however, no differences are observed in the number of primordial follicles
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• some secondary follicles exhibit an irregular/incomplete second layer of granulosa cells and often contain a degenerating oocyte
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• percent of follicles in the secondary stage is significantly lower than in controls (17% versus 45%)
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• adult females show a ~30% reduction in ovary size relative to control females
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• in whole ovaries, mRNA levels of Gdf9 and Bmp15 are nearly undetectable, whereas mRNA levels of Bmp6, Kit, and Kitl are significantly increased relative to control ovaries
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• although vaginal cytology indicates estrus stage changes, no regular cycle or periodicity is observed during a 3-wk test period indicating failure of estrus cycling
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• when placed individually with wild-type males, 6-wk-old females never appeared pregnant or produced offspring
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homeostasis/metabolism
behavior/neurological
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• vaginal plugs are infrequently detected during a 5-mo breeding trial
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cellular
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• oocytes rarely grow larger than 50 um in diameter, indicating arrested oocyte growth
• oocyte-specific expression of Gdf9 and Bmp15 is nearly undetectable
• oocytes exhibit altered levels of several oocyte-specific factors, including Pou5f1, Figla, Lhx8, Oosp1, and Sohlh2
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• secondary follicles often contain a degenerating oocyte
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endocrine/exocrine glands
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• no mature follicles are observed
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• percent of follicles in the primary stage is significantly higher than in controls (83% versus 20%)
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• no multilayered, antral follicles or Graafian follicles are observed
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• ovarian follicle maturation is halted; no post-secondary follicles are observed
• however, no differences are observed in the number of primordial follicles
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• some secondary follicles exhibit an irregular/incomplete second layer of granulosa cells and often contain a degenerating oocyte
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• percent of follicles in the secondary stage is significantly lower than in controls (17% versus 45%)
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• adult females show a ~30% reduction in ovary size relative to control females
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• in whole ovaries, mRNA levels of Gdf9 and Bmp15 are nearly undetectable, whereas mRNA levels of Bmp6, Kit, and Kitl are significantly increased relative to control ovaries
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Analysis Tools