Yy1^tm1Yshi
Targeted Allele Detail

Summary

• Symbol: Yy1^tm1Yshi
• Name: YY1 transcription factor; targeted mutation 1, Yang Shi
• MGI ID: MGI:2445451
• Synonyms: YY1^-, Yy1^delta
• Gene: Yy1 Location: Chr12:108758899-108786074 bp, + strand Genetic Position: Chr12, 59.58 cM
• Alliance: Yy1^tm1Yshi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57857
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 1 and the proximal promoter region was replaced with a neomycin selection cassette via homologous recombination. The deleted region encoded 227 of the 414 amino acids in the endogenous protein. No protein was detected in homozygous mutant embryos by immunostaining. (J:57857)

Expression

In Mice Carrying this Mutation:	57 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yy1 Mutation: 34 strains or lines available

References

• Original: J:57857 Donohoe ME, et al., Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999 Oct;19(10):7237-44
• All: 8 reference(s)