All Phenotypes Tbx18<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tbx18⁺
wild type
MGI:2441023

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Sox2^tm4.1Skn/Sox2^tm4.1Skn Tbx18^{tm2.1(cre)Sev}/Tbx18⁺	involves: 129S1/Sv	MGI:5461657
cn2	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI	MGI:5576973
cn3	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/SvImJ * NMRI	MGI:5576974
cn4	Hprt1^{tm3(CAG-Tbx18,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129S1/SvImJ * NMRI	MGI:5576972
cn5	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺ Wt1^tm1Jae/Wt1^tm1Jae	involves: 129S4/SvJae	MGI:3841149
cn6	Fkbp1a^tm1.1Shou/Fkbp1a^tm1Zuk Tbx18^tm2(cre)Sev/Tbx18⁺	involves: 129S7/SvEvBrd	MGI:5490250
cn7	Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺	involves: 129/Sv * 129S1/SvImJ * NMRI	MGI:4849535

Allelic Composition	Sox2^tm4.1Skn/Sox2^tm4.1Skn Tbx18^{tm2.1(cre)Sev}/Tbx18⁺
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox2^tm4.1Skn mutation (1 available); any Sox2 mutation (56 available)
Tbx18^{tm2.1(cre)Sev} mutation (0 available); any Tbx18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:191082 )

abnormal hair growth ( J:191082 )

• hair shaft outgrowth is markedly delayed after birth compared to controls (heterozygotes); guard hair shaft lengths are significantly shorter than controls at P8 and later stages, indicating reduced outgrowth speed

• guard and awl/auchene hairs are 20-55% shorter in mutants, while zigzag hairs are comparable to heterozygous controls

• proliferation and differentiation of matrix progenitor cells are normal

• BrdU labeling of matrix cells at P5 indicates that, while proliferation is normal in mutants, the rate of transition into the hair shaft area is delayed; delay in migration is observed up to 48 hours after BrdU injection; upward movement of differentiation matrix progenitor cells is impaired

• migration of hair shaft progenitors in mutant zigzag follicles is much slower than in control guard hairs; migration speed of mutant guard hairs is reduced and becomes comparable to the speed of migration of control or mutant zigzag follicles

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (1095 available)
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1280 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal epicardium development ( J:210076 )

• epicardial cells exhibit premature smooth muscle cell differentiation and fail to invade into the right ventricular myocardium unlike in wild-type mice

Allelic Composition	Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm4(CAG-Tbx18*,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1280 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:210076 )

• mice die at E14.5

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• cardiomyocytes apoptosis and size are normal

abnormal sinus venosus morphology ( J:210076 )

• sinus horn defects

heart hypoplasia ( J:210076 )

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

abnormal pericardium morphology ( J:210076 )

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

cellular

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

muscle

thin ventricle myocardium compact layer ( J:210076 )

• beginning at E12.5 and worsening at E14.5

decreased fetal cardiomyocyte proliferation ( J:210076 )

• in the right ventricular myocardium at E12.5 and E13.5

Allelic Composition	Hprt1^{tm3(CAG-Tbx18,-Venus)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm3(CAG-Tbx18,-Venus)Akis} mutation (0 available); any Hprt1 mutation (1280 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:210076 )

• although present in Mendelian ratios at E18.5, mice are not recovered after birth

cardiovascular system

cardiovascular system phenotype ( J:210076 )

N	• heart morphology is normal at E18.5

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Tbx18^tm4(cre)Akis/Tbx18⁺ Wt1^tm1Jae/Wt1^tm1Jae
Genetic Background	involves: 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (10 available); any Gt(ROSA)26Sor mutation (1095 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (34 available)
Wt1^tm1Jae mutation (3 available); any Wt1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal epicardium development ( J:147421 )

• the formation of the epicardium is severely compromised in E12.5 embryos

Allelic Composition	Fkbp1a^tm1.1Shou/Fkbp1a^tm1Zuk Tbx18^tm2(cre)Sev/Tbx18⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fkbp1a^tm1.1Shou mutation (0 available); any Fkbp1a mutation (12 available)
Fkbp1a^tm1Zuk mutation (0 available); any Fkbp1a mutation (12 available)
Tbx18^tm2(cre)Sev mutation (0 available); any Tbx18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:195489 )

N	• animals show normal ventricular chamber formation; normal trabeculation and compaction in ventricles are observed

Allelic Composition	Hprt1^{tm1(CAG-Sox9,-EGFP)Akis}/Y Tbx18^tm4(cre)Akis/Tbx18⁺
Genetic Background	involves: 129/Sv * 129S1/SvImJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(CAG-Sox9,-EGFP)Akis} mutation (0 available); any Hprt1 mutation (1280 available)
Tbx18^tm4(cre)Akis mutation (0 available); any Tbx18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal ureter morphology ( J:166547 )

• mice exhibit excessive deposition of glycosamiglycans/mucopolysaccharides compared with wild-type mice

• the composition of ureter extracellular matrix is altered compared to in wild-type mice

• however, radial patterning of ureteric mesenchyme is normal

abnormal ureter smooth muscle morphology ( J:166547 )

• mice exhibit disorganized smooth muscle layers in the ureters with round smooth muscle cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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